Celebrating Twenty Years of People Who Make ATS Special
Celebrating Twenty Years of People Who Make ATS Special Read More »
Cover Article: Celebrating Twenty Years of Science Advanced Targeting Systems (founded 22 Apr 1994)
Advanced Targeting Systems’ first product, 192-IgG-SAP, answered a long-sought request from behavioral neuroscientists: a neurotoxin for the cholinergic neurons of the basal forebrain. Over the years it has become the classic in the field and has changed the way that we think about those neurons and their role in learning and memory. Substance P-saporin (SP-SAP)
p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells
Forsyth PA, Krishna N, Lawn S, Valadez JG, Qu X, Fenstermacher DA, Fournier M, Potthast L, Chinnaiyan P, Gibney GT, Zeinieh M, Barker PA, Carter BD, Cooper MK, Kenchappa RS (2014) p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells. J Biol Chem 289(12):8067-8085. doi: 10.1074/jbc.M113.513762 PMID:
Role for monocyte chemoattractant protein-1 in the induction of chronic muscle pain in the rat.
Alvarez P, Green P, Levine J (2014) Role for monocyte chemoattractant protein-1 in the induction of chronic muscle pain in the rat. Pain 155:1161-1167. doi: 10.1016/j.pain.2014.03.004 Summary: In order to better understand where monocyte chemoattractant protein 1 (MCP-1) fits in the chronic pain landscape the authors performed a series of experiments using antisense and mismatch
TrkA in vivo function is negatively regulated by ubiquitination.
Kiris E, Wang T, Yanpallewar S, Dorsey S, Becker J, Bavari S, Palko M, Coppola V, Tessarollo L (2014) TrkA in vivo function is negatively regulated by ubiquitination. J Neurosci 34:4090-4098. doi: 10.1523/JNEUROSCI.4294-13.2014 PMID: 24623787 Summary: The high affinity nerve growth factor receptor, trkA, plays an intrinsic role in the regulation of various aspects of
TrkA in vivo function is negatively regulated by ubiquitination. Read More »
Habenular kisspeptin modulates fear in the zebrafish.
Ogawa S, Nathan FM, Parhar IS (2014) Habenular kisspeptin modulates fear in the zebrafish. Proc Natl Acad Sci U S A 111(10):3841-3846. doi: 10.1073/pnas.1314184111 PMID: 24567386 Summary: The peptide kisspeptin can be found in several areas of the brain, but its role in regions other than the hypothalamus has not been studied. Zebrafish express kiss1
Habenular kisspeptin modulates fear in the zebrafish. Read More »
Depletion of alloreactive T cells by anti-CD137-saporin immunotoxin.
Lee SC, Seo KW, Kim HJ, Kang SW, Choi HJ, Kim A, Kwon BS, Cho HR, Kwon B (2015) Depletion of alloreactive T cells by anti-CD137-saporin immunotoxin. Cell Transplant 24:1167-1181. doi: 10.3727/096368914X679327 Summary: The ability to selectively remove T cells that mediate graft-versus-host disease (GVHD) would prevent graft rejection as well as preserve the T
Depletion of alloreactive T cells by anti-CD137-saporin immunotoxin. Read More »
The combinational use of CRISPR/Cas9-based gene editing and targeted toxin technology enables efficient biallelic knockout of the α-1,3-galactosyltransferase gene in porcine embryonic fibroblasts.
Sato M, Miyoshi K, Nagao Y, Nishi Y, Ohtsuka M, Nakamura S, Sakurai T, Watanabe S (2014) The combinational use of CRISPR/Cas9-based gene editing and targeted toxin technology enables efficient biallelic knockout of the α-1,3-galactosyltransferase gene in porcine embryonic fibroblasts. Xenotransplantation 21:291-300. doi: 10.1111/xen.12089 Summary: Results indicate that a combination of the CRISPR/Cas9 system and
The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines.
Lund K, Bostad M, Skarpen E, Braunagel M, Krauss S, Duncan A, Hogset A, Selbo P (2014) The novel EpCAM-targeting monoclonal antibody 3-17I linked to saporin is highly cytotoxic after photochemical internalization in breast, pancreas and colon cancer cell lines. MAbs 6(4):1038-1050. doi: 10.4161/mabs.28207 Summary: The epithelial cell adhesion molecule (EpCAM) is an attractive diagnostic
Stimulation of feeding by three different glucose-sensing mechanisms requires hindbrain catecholamine neurons.
Li AJ, Wang Q, Dinh TT, Powers BR, Ritter S (2014) Stimulation of feeding by three different glucose-sensing mechanisms requires hindbrain catecholamine neurons. Am J Physiol Regul Integr Comp Physiol 306(4):R257-R264. doi: 10.1152/ajpregu.00451.2013 Summary: The glucoregulatory system of the brain requires catecholamine neurons in the hindbrain. he sensory mechanisms and connected circuitry controlling the response