Kristen Hartman – Page 137 – Advanced Targeting Systems

Acute hypoxia activates hypothalamic paraventricular nucleus-projecting catecholaminergic neurons in the C1 region.

Silva T, Takakura A, Moreira T (2016) Acute hypoxia activates hypothalamic paraventricular nucleus-projecting catecholaminergic neurons in the C1 region. Exp Neurol 285:1-11. doi: 10.1016/j.expneurol.2016.08.016 Summary: Catecholaminergic C1 cells reside in the rostral and intermediate portions of the ventrolateral medulla (RVLM) and can be activated by hypoxia. These neurons regulate the hypothalamic pituitary axis via direct […]

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Selective noradrenaline depletion impairs working memory and hippocampal neurogenesis.

Kristen Hartman

Coradazzi M, Gulino R, Fieramosca F, Falzacappa L, Riggi M, Leanza G (2016) Selective noradrenaline depletion impairs working memory and hippocampal neurogenesis. Neurobiol Aging 48:93-102. doi: 10.1016/j.neurobiolaging.2016.08.012 Summary: Neuronal loss in the locus coeruleus (LC) of Alzheimer’s patients is well known, but the contribution of LC-derived noradrenergic afferents to learning and memory function is unknown.

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Reducing falls in Parkinson’s disease: interactions between donepezil and the 5‐HT6 receptor antagonist idalopirdine on falls in a rat model of impaired cognitive control of complex movements

Kristen Hartman

Kucinski A, de Jong IEM, Sarter M (2017) Reducing falls in Parkinson’s disease: interactions between donepezil and the 5‐HT6 receptor antagonist idalopirdine on falls in a rat model of impaired cognitive control of complex movements. Eur J Neurosci 45:217-231.. doi: 10.1111/ejn.13354 Objective: To assess the effects of treatment on MCMCT performance and attention in DL

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Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming.

Kristen Hartman

Araldi D, Ferrari L, Levine J (2016) Gi-protein-coupled 5-HT1B/D receptor agonist sumatriptan induces type I hyperalgesic priming. Pain 157:1773-1782. doi: 10.1097/j.pain.0000000000000581 Summary: The present study explored the possibility that, like MOR and A1-adenosine receptor agonists, triptans would also induce type II hyperalgesic priming. In addition, they explored the 5-HT receptor subtypes at which triptans act

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Antibody therapy targeting CD47 and CD271 effectively suppresses melanoma metastasis in patient-derived xenografts.

Kristen Hartman

Ngo M, Han A, Lakatos A, Sahoo D, Hachey S, Weiskopf K, Beck A, Weissman I, Boiko A (2016) Antibody therapy targeting CD47 and CD271 effectively suppresses melanoma metastasis in patient-derived xenografts. Cell Rep 16:1701-1716. doi: 10.1016/j.celrep.2016.07.004 Summary: The high rate of metastasis and recurrence among melanoma patients indicates the presence of cells within melanoma

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Nucleus incertus contributes to an anxiogenic effect of buspirone in rats: Involvement of 5-HT1A receptors.

Kristen Hartman

Kumar J, Rajkumar R, Lee L, Dawe G (2016) Nucleus incertus contributes to an anxiogenic effect of buspirone in rats: Involvement of 5-HT1A receptors. Neuropharmacology 110:1-14. doi: 10.1016/j.neuropharm.2016.07.019 Summary: The nucleus incertus (NI) is involved in stress and anxiety responses. The NI is a cluster of GABAergic neurons in the brainstem, and coexpresses CRF, 5-HT1A

Nucleus incertus contributes to an anxiogenic effect of buspirone in rats: Involvement of 5-HT1A receptors. Read More »

Cover Article: Targeted depletion of hematopoietic stem cells promises safer transplantation

News Article / Kristen Hartman

By Rahul Palchaudhuri, Ph.D., Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts, USA Hematopoietic stem cell transplantation (HSCT) has been clinically used for 58 years and offers life-saving therapies for a variety of malignant and non-malignant blood disorders. Currently 50,000 transplants are performed globally per year with 90% of these for the

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Toolbox: Orexin Receptor Antibody Conjugates

News Tools / Kristen Hartman

Anti-OX1R-SAP (Cat. #BETA-007) eliminates mouse, rat, and guinea pig cells expressing the orexin 1 receptor. All other cells are left untouched. Anti-OX2R-SAP (Cat. #BETA-008) eliminates rat cells expressing the orexin 2 receptor (OX2R). All other cells are left untouched. These two immunotoxins are being offered as part of our Beta Testing program. They have not

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Toolbox: Orexin-B-SAP

News Tools / Kristen Hartman

ATS is pleased to re-release a product and kit specific for the Orexin 2 receptor (OX2R). The Orexin 1 and Orexin 2 receptors are found in the perifornical area/latero-posterior hypothalamus, and projections from this area cover much of the brain. These receptors have been implicated in various neurophysiological and neuropsychological disorders such as narcolepsy, insomnia,

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From the President: What’s ZAP?

News Article / Kristen Hartman

Wuzzup? No. What’s ZAP? Some of our products have SAP in the name, like 192-IgG-SAP (Cat. #IT-01). Some of our products have ZAP in the name, like Hum-ZAP (Cat. #IT-22). First, what’s the same about ZAP and SAP? They both mean Saporin. The payload that Advanced Targeting Systems made famous to specifically eliminate targeted cells.

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Author name: Kristen Hartman