Wiley RG (2016) Featured Article: Cerebral cholinergic lesion reduces operant responses to unpleasant thermal stimuli. Targeting Trends 17(2) Related Products: 192-IgG-SAP (Cat. #IT-01) Read the featured article in Targeting Trends.
ATS is pleased to present a new product line specific for the vesicular GABA transporter (vGAT) protein. vGAT mediates both the accumulation of GABA into synaptic vesicles and its release from nerve terminals. vGAT is expressed in nerve endings of GABAergic neurons throughout the CNS. The GABAergic system is crucial to the development and functional
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CHOp75 Cells 192-IgG-SAP is the #1 rat p75-lesioning tool available for research use. Our development of CHOp75 cells grew from the need for a stable, reliable cell line to use for Quality Control of each new lot of 192-IgG-SAP. Now, these cells are available for use in laboratories worldwide. CHOp75 cells are standard CHO (Chinese
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The fundamental things apply. “The Peptidergic Control Circuit for Sighing,” recently published in the prestigious journal Nature, has made us rethink our fundamental belief that sighs are only “long, deep breaths expressing sadness, relief or exhaustion.” Often prompting someone to say, “What’s wrong?” As it turns out, sighs “also occur spontaneously every few minutes to
From the President: A Sigh is (Not) Just a Sigh . . . Read More »
by Ronald G. Wiley, M.D., Ph.D., Departments of Neurology and Pharmacology, Vanderbilt University, Nashville, TN and C. J. Vierck, Department of Neuroscience, McKnight Brain Institute, University of Florida College of Medicine, Gainesville, FL, USA Degeneration of the cholinergic basal forebrain (CBF: medial septum, diagonal band of Broca, nucleus basalis of Meynert/substantia innominata) is a prominent
Schwartz M, Nguyen A, Warrier D, Palmerston J, Thomas A, Morairty S, Neylan T, Kilduff T (2016) Locus coeruleus and tuberomammillary nuclei ablations attenuate hypocretin/orexin antagonist-mediated rem sleep. eNeuro 3:ENEURO.0018-0016.2016. doi: 10.1523/ENEURO.0018-16.2016 Summary: To examine the mechanism by which the Orexin 1r/Orexin 2r antagonist almorexant decreases wakefulness and increases NREM and REM sleep the authors
Mao C, Agca C, Mocko-Strand J, Wang J, Ullrich-Lüter E, Pan P, Wang S, Arnone M, Frishman L, Klein W (2016) Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development. Proc Biol Sci 283:20152978. doi: 10.1098/rspb.2015.2978 PMID: 26962139 Summary: Pou4f2 is Pou domain transcription factor that is essential for
Yao Y, Echeverry S, Shi X, Yang M, Yang Q, Wang G, Chambon J, Wu Y, Fu K, De Koninck Y, Zhang J (2016) Dynamics of spinal microglia repopulation following an acute depletion. Sci Rep 6:22839. doi: 10.1038/srep22839 Summary: This study confirms that similar to microglia in the brain, spinal microglia can repopulate rapidly following
Dynamics of spinal microglia repopulation following an acute depletion. Read More »
Fei Y, Wang X, Chen S, Zhou Q, Zhang C, Li Y, Sun L, Zhang L (2016) Role of the RVM in descending pain regulation originating from the cerebrospinal fluid-contacting nucleus. Neurochem Res 41:1651-1661. doi: 10.1007/s11064-016-1880-6 Summary: The researchers investigated whether the CSF-contacting nucleus contributed to descending pain modulation in normal and neuropathic rats, and
Gritsch S, Bali K, Kuner R, Vardeh D (2016) Functional characterization of a mouse model for central post-stroke pain. Mol Pain 12:1744806916629049. doi: 10.1177/1744806916629049 Summary: While clinical evidence has pointed toward central pain pathway dysfunction in central post-stroke pain (CPSP), the underlying mechanisms have not been defined. In this work the authors created a mouse
Functional characterization of a mouse model for central post-stroke pain. Read More »