Kumar JR, Rajkumar R, Lee LC, Dawe GS (2016) Featured Article: Targeted lesioning reveals role of nucleus incertus in the anxiogenic effect of buspirone. Targeting Trends 17(4) Related Products: CRF-SAP (Cat. #IT-13) Read the featured article in Targeting Trends. See Also: Kumar J et al. Nucleus incertus contributes to an anxiogenic effect of buspirone in […]
Paban V, Valable S, Baril N, Gilbert V, Chambon C, & Alescio-Lautier B (2016) Neuronal and glial changes in rat hippocampal formation after cholinergic deafferentation. J Biomol Res Ther 5(3):1000147. doi: 10.4172/2167-7956.1000147 Summary: The effects of cholinergic insult were studied in the hippocampal formation of cholinergic lesioned rats at metabolic and cellular levels by in
Cai Y, Chew C, Muñoz F, Sengelaub D (2017) Neuroprotective effects of testosterone metabolites and dependency on receptor action on the morphology of somatic motoneurons following the death of neighboring motoneurons. Dev Neurobiol 77:691-707.. doi: 10.1002/dneu.22445 Summary: In this study the authors examined whether the protective effects of testosterone could be mediated via its androgenic
By Jigna Rajesh Kumar, [a, b, c, d] Ramamoorthy Rajkumar, [a, b, c] Liying Corinne Lee, [a, b, c] Gavin S. Dawe [a, b, c, d][a] Dept Pharmacology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, 117600, Singapore [b] Neurobiology and Ageing Programme, Life Sciences Institute, National University of
Ueki Y, Ramirez G, Salcedo E, Stabio ME, Lefcort F (2016) Loss of Ikbkap causes slow, progressive retinal degeneration in a mouse model of familial dysautonomia. eNeuro 3:ENEURO.0143-0116.2016. doi: 10.1523/eneuro.0143-16.2016 PMID: 27699209 Summary: Familial dysautonomia (FD) is an autosomal recessive congenital neuropathy that is caused by a mutation in the gene for inhibitor of kappa
Amano M, Amiya N, Yokoyama T, Onikubo K, Yamamoto N, Takahashi A (2016) Immunohistochemical detection of corticotropin-releasing hormone (CRH) in the brain and pituitary of the hagfish, Eptatretus burgeri. Gen Comp Endocrinol 236:174-180. doi: 10.1016/j.ygcen.2016.07.018 PMID: 27444128 Summary: The distribution of corticotropin-releasing hormone (CRH) in the brain and pituitary of the hagfish Eptatretus burgeri, representing
Nohara S, Kato K, Fujiwara D, Sakuragi N, Yanagihara K, Iwanuma Y, Kajiyama Y (2016) Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer. Clin Res Hepatol Gastroenterol 40:494-503. doi: 10.1016/j.clinre.2015.11.003 Summary: Scirrhous gastric cancer has the worst prognosis of gastric carcinoma, and treatment with standard cancer therapies has had minimal success. In
Aminopeptidase N (APN/CD13) as a target molecule for scirrhous gastric cancer. Read More »
Huang WC (2016) Stem cells in tissue regeneration and diseases. University of California, Berkeley Thesis. Objective: To investigate the therapeutic effect of induced pluripotent stem cell-derived neural crest stem cells (iPSC-NCSCs) and mesenchymal progenitor cells (MPCs) on peripheral nerve regeneration. Summary: Transplantation of NCSCs has better outcomes of motor nerve recovery and muscle reinnervation by
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Young J (2016) Hunger, thirst, sex, and sleep: How the brain controls our passions. Rowman & Littlefield Publishers. Summary: The author reviews what has been learned about feeding, “Other clever techniques have confirmed that leptin specifically acts upon NPY-containing neurons to depress feeding. One technique is to infuse the hypothalamus with a form of NPY
Hunger, thirst, sex, and sleep: How the brain controls our passions Read More »