Author name: Kristen Hartman

A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors.

Targeting Topics /

A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors. Shramm PA, Ancheta L, Higgins D, Lappi DA (2017) Society for Neuroscience, Washington, DC. Abstract Some of the most recent successes in the treatment of cancers have been from antibodies to cell surface proteins […]

A rapid, pH-sensitive screening method to detect internalization of cell surface markers for development of antibody-based pharmaceuticals to treat brain tumors. Read More »

The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2

Watts NR, Eren E, Palmer I, Huang PL, Huang PL, Shoemaker RH, Lee-Huang S, Wingfield PT (2023) The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2. PLoS One 18(6):e0286370. doi: 10.1371/journal.pone.0286370 PMID: 37384752 Summary: Saporin is mentioned in the discussion of RIPs and their usage as antivirals. Related Products: Saporin (Cat. #PR-01) See Also: Arslan I

The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2 Read More »

A Comparison of Cellular Uptake Mechanisms, Delivery Efficacy, and Intracellular Fate Between Liposomes and Extracellular Vesicles

Gandek TB, van der Koog L, Nagelkerke A (202329) A Comparison of Cellular Uptake Mechanisms, Delivery Efficacy, and Intracellular Fate Between Liposomes and Extracellular Vesicles. Adv Healthc Mater e2300319 doi: 10.1002/adhm.202300319 PMID: 37384827 Objective: Using peptide-functionalized extracellular vesicles (EVs), filled with saporin, to increase cytotoxicity over normal biological EVs. Summary: Extracellular vesicles were used as

A Comparison of Cellular Uptake Mechanisms, Delivery Efficacy, and Intracellular Fate Between Liposomes and Extracellular Vesicles Read More »

The gut-brain axis mediates bacterial driven modulation of reward signaling

Kim JS, Williams KC, Kirkland RA, Schade R, Freeman KG, Cawthon CR, Rautmann AW, Smith JM, Edwards GL, Glenn TC, Holmes PV, de Lartigue G, de La Serre CB (2023) The gut-brain axis mediates bacterial driven modulation of reward signaling. Mol Metab 26:101764. doi: 10.1016/j.molmet.2023.101764 PMID: 37380023 Objective: To investigate the role of gut microbiota

The gut-brain axis mediates bacterial driven modulation of reward signaling Read More »

Streptavidin-pHast: A readily conjugatable, pH-sensitive dye to screen for internalization

Targeting Topics /

Streptavidin-pHast: A readily conjugatable, pH-sensitive dye to screen for internalization Shramm PA, Ancheta L (2019) Proceedings of the American Association for Cancer Research Annual Meeting, Atlanta GA. Abstract The quick and efficient screening of targeting agents that internalize effectively is vital for determining suitability as potential therapeutics. Some of the most recent successes in the

Streptavidin-pHast: A readily conjugatable, pH-sensitive dye to screen for internalization Read More »

Self-assembled nanogels consisting of cholesterol-bearing polysaccharides and their applications in medicine

Antonia-Nancy H, Matsumoto M, Tahara Y (2023) Self-assembled nanogels consisting of cholesterol-bearing polysaccharides and their applications in medicine. (eds. Dr. Chukwuebuka Emmanuel Umeyor, Dr. Emmanuel Uronnachi and Dr. Pratik Kakade). In: Hydrogels and Nanogels – Applications in Medicine doi: 10.5772/intechopen.1001981 Objective: Using iron oxide-containing nano-gels containing saporin to magnetically guide the targeting of saporin. Summary:

Self-assembled nanogels consisting of cholesterol-bearing polysaccharides and their applications in medicine Read More »

Direct cytosolic delivery of proteins and CRISPR-Cas9 genome editing by gemini amphiphiles via non-endocytic translocation pathways

Le Z, Pan Q, He A, Liu H, Shi Y, Liu L, Liu Z, Ping Y, Chen Y (2023) Direct cytosolic delivery of proteins and CRISPR-Cas9 genome editing by gemini amphiphiles via non-endocytic translocation pathways. ACS Cent Sci 9(7):1313-1326. doi: 10.1021/acscentsci.3c00207 PMID: 37521791 Objective: Create a library composed of 150 gemini amphiphiles (GAs), a molecule

Direct cytosolic delivery of proteins and CRISPR-Cas9 genome editing by gemini amphiphiles via non-endocytic translocation pathways Read More »

Neuromedin B-expressing neurons in the retrotrapezoid nucleus regulate respiratory homeostasis and promote stable breathing in adult mice

Souza GMPR, Stornetta DS, Shi Y, Lim E, Berry FE, Bayliss DA, Abbott SBG (2023) Neuromedin B-expressing neurons in the retrotrapezoid nucleus regulate respiratory homeostasis and promote stable breathing in adult mice. J Neurosci JN-RM-0386-23. doi: 10.1523/JNEUROSCI.0386-23.2023 PMID: 37290937 Objective: To develop a transgenic mouse model and demonstrate that retrotrapezoid nucleus (RTN) neurons are fundamental

Neuromedin B-expressing neurons in the retrotrapezoid nucleus regulate respiratory homeostasis and promote stable breathing in adult mice Read More »

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