Author name: Kristen Hartman

From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity?

Ardini M, Vago R, Fabbrini MS, Ippoliti R (2022) From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity?. Toxins (Basel) 14(9):579. doi: 10.3390/toxins14090579 PMID: 36136517 Objective: To give an overview describing some of the bacterial and plant enzymes studied so far for their delivery and controlled expression in tumor models. Summary: “Suicide […]

From immunotoxins to suicide toxin delivery approaches: Is there a clinical opportunity? Read More »

Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice

Cleverdon REG, Braun JL, Geromella MS, Whitley KC, Marko DM, Hamstra SI, Roy BD, MacPherson REK, Fajardo VA (2022) Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice. iScience 25(9):104972. doi: 10.1016/j.isci.2022.104972 PMID: 36093052 Objective: To investigate whether sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA) function would differ in muscles from

Sarco(endo)plasmic reticulum Ca2+-ATPase function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice Read More »

Bovine bone gelatin-derived peptides: Food processing characteristics and evaluation of antihypertensive and antihyperlipidemic activities

Cao S, Wang Z, Xing L, Zhou L, Zhang W (2022) Bovine bone gelatin-derived peptides: Food processing characteristics and evaluation of antihypertensive and antihyperlipidemic activities. J Agric Food Chem 70(32):9877-9887. doi: 10.1021/acs.jafc.2c02982 PMID: 35917452 Objective: To evaluate the food processing properties of bovine bone gelatin-derived peptides (BGPs) and their effects and mechanisms on hypertension and

Bovine bone gelatin-derived peptides: Food processing characteristics and evaluation of antihypertensive and antihyperlipidemic activities Read More »

In vivo visualization and molecular targeting of the cardiac conduction system

Goodyer WR, Beyersdorf BM, Duan L, van den Berg NS, Mantri S, Galdos FX, Puluca N, Buikema JW, Lee S, Salmi D, Robinson ER, Rogalla S, Cogan DP, Khosla C, Rosenthal EL, Wu SM (2022) In vivo visualization and molecular targeting of the cardiac conduction system. J Clin Invest e156955. doi: 10.1172/jci156955 Objective: To engineer

In vivo visualization and molecular targeting of the cardiac conduction system Read More »

Self-assembling nanocarriers from engineered proteins: Design, functionalization, and application for drug delivery

Li Y, Champion JA (2022) Self-assembling nanocarriers from engineered proteins: Design, functionalization, and application for drug delivery. Adv Drug Deliv Rev 189:114462. doi: 10.1016/j.addr.2022.114462 PMID: 35934126 Objective: Review recent advances in protein nano-carriers that are from ground-up design recombinant proteins. Summary: Nanocarriers with a size range of 10-200 nm have emerged as platforms with significant

Self-assembling nanocarriers from engineered proteins: Design, functionalization, and application for drug delivery Read More »

Cannabinoid receptors and glial response following a basal forebrain cholinergic lesion

Llorente-Ovejero A, Bengoetxea de Tena I, Martínez-Gardeazabal J, Moreno-Rodríguez M, Lombardero L, Manuel I, Rodríguez-Puertas R (2022) Cannabinoid receptors and glial response following a basal forebrain cholinergic lesion. ACS Pharmacol Transl Sci 5(9):791-802. doi: 10.1021/acsptsci.2c00069 PMID: 36110372 Objective: The endocannabinoid system is involved in the control of learning, memory, and neuroinflammatory processes and plays a

Cannabinoid receptors and glial response following a basal forebrain cholinergic lesion Read More »

Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis

Orciani C, Hall H, Pentz R, Foret MK, Do Carmo S, Cuello AC (2022) Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis. J Neurochem doi: 10.1111/jnc.15683 Objective: To determine whether reciprocal interaction of basal forebrain cholinergic neurons (BFCN) impact neurotrophin availability and affect

Long-term nucleus basalis cholinergic depletion induces attentional deficits and impacts cortical neurons and BDNF levels without affecting the NGF synthesis Read More »

Stimulation of Akt phosphorylation and glucose transport by metalloporphyrins with peroxynitrite decomposition catalytic activity

Eccardt AM, Pelzel RJ, Bell TP, Fisher JS (2022) Stimulation of Akt phosphorylation and glucose transport by metalloporphyrins with peroxynitrite decomposition catalytic activity. Catalysts 12(8):849. doi: 10.3390/catal12080849 PMID: 0 Objective: To determine whether a catalytic action of iron porphyrin compounds would be related to their stimulation of insulin signaling and glucose uptake in C2C12 myotubes.

Stimulation of Akt phosphorylation and glucose transport by metalloporphyrins with peroxynitrite decomposition catalytic activity Read More »

Perinatal correlated retinal activity is required for the wiring of visual axons in non-image forming nuclei

Negueruela S, Morenilla C, Herrera M, Coca Y, Florez-Paz D, López-Cascales MT, Gomis A, Herrera E (2022) Perinatal correlated retinal activity is required for the wiring of visual axons in non-image forming nuclei. bioRxiv 2022.07.27.501692. doi: 10.1101/2022.07.27.501692 Related Products: Melanopsin Rabbit Polyclonal (Cat. #AB-N38)

Perinatal correlated retinal activity is required for the wiring of visual axons in non-image forming nuclei Read More »

Differential role of GABAergic and cholinergic ventral pallidal neurons in behavioral despair, conditioned fear memory and active coping.

Akmese C, Sevinc C, Halim S, Unal G (2022) Differential role of GABAergic and cholinergic ventral pallidal neurons in behavioral despair, conditioned fear memory and active coping. bioRxiv 2022.07.21.500949. doi: 10.1101/2022.07.21.500949 Related Products: 192-IgG-SAP (Cat. #IT-01), GAT1-SAP (Cat. #IT-32)

Differential role of GABAergic and cholinergic ventral pallidal neurons in behavioral despair, conditioned fear memory and active coping. Read More »

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