Author name: Kristen Hartman

Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways

Ullah K, Rosendahl AH, Izzi V, Bergmann U, Pihlajaniemi T, Maki JM, Myllyharju JA-Ohoo (2017) Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways. Sci Rep 7:172200. doi: 10.1038/s41598-017-17376-0 PMID: 29222481 Usage: Western blot Related Products: Trans-4-Hydroxy-L-Proline Rabbit Polyclonal, Conjugated (Cat. #AB-T044)

Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways Read More »

Neurotrophically induced mesenchymal progenitor cells derived from induced pluripotent stem cells enhance neuritogenesis via neurotrophin and cytokine production

Brick RM, Sun AX, Tuan RSA-Ohoo (2018) Neurotrophically induced mesenchymal progenitor cells derived from induced pluripotent stem cells enhance neuritogenesis via neurotrophin and cytokine production. Stem Cells Transl Med 7:45-58. doi: 10.1002/sctm.17-0108 PMID: 29215199 Objective: To examine the potential utility of an alternative, mesenchymal-like cell (MSCs) source, derived from induced pluripotent stem cells, termed induced

Neurotrophically induced mesenchymal progenitor cells derived from induced pluripotent stem cells enhance neuritogenesis via neurotrophin and cytokine production Read More »

IB4-SAP to study mechanical hyperalgesia

Targeting Topics /

To determine which subtype of nociceptor, peptidergic or non-peptidergic, is involved in the mechanical hyperalgesia induced by LMWH (low molecular weight hyaluronan), rats were pretreated with neurotoxins previously shown to selectively deplete these two types of sensory neurons:  Isolectin B4 (IB4)-saporin (SAP), which acts on IB4-positive, non-peptidergic neurons (Cat. #IT-10 IB4-SAP), and substance P-saporin (Cat.

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Neuromedin B and Itch

Targeting Topics /

To examine the role of NMBR+ dorsal horn neurons in itch and pain transmission, the authors treated mice with NMB-SAP (Cat. #IT-70; 2–3 μg, i.t.) at which no side effects were observed. NMB-SAP treated mice barely showed scratching behaviors, whereas control mice exhibited NMB-induced scratching with a rapid onset of scratching responses. These data demonstrate

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Regulation of reentrainment function is dependent on a certain minimal number of intact functional iprgcs in rd mice

Zhang J, Wang H, Wu S, Liu Q, Wang N (2017) Regulation of reentrainment function is dependent on a certain minimal number of intact functional iprgcs in rd mice. J Ophthalmol 2017:6804853.. doi: 10.1155/2017/6804853 Related Products: Melanopsin-SAP (Cat. #IT-44)

Regulation of reentrainment function is dependent on a certain minimal number of intact functional iprgcs in rd mice Read More »

Attenuation of the infiltration of angiotensin ii expressing CD3+ T-cells and the modulation of nerve growth factor in lumbar dorsal root ganglia – a possible mechanism underpinning analgesia produced by EMA300, an Angiotensin II type 2 (AT2) receptor antagonist

Khan N, Muralidharan A, Smith MT (2017) Attenuation of the infiltration of angiotensin ii expressing CD3+ T-cells and the modulation of nerve growth factor in lumbar dorsal root ganglia – a possible mechanism underpinning analgesia produced by EMA300, an Angiotensin II type 2 (AT2) receptor antagonist. Front Mol Neurosci 10:389. doi: 10.3389/fnmol.2017.00389 PMID: 29200998 Objective:

Attenuation of the infiltration of angiotensin ii expressing CD3+ T-cells and the modulation of nerve growth factor in lumbar dorsal root ganglia – a possible mechanism underpinning analgesia produced by EMA300, an Angiotensin II type 2 (AT2) receptor antagonist Read More »

A streamlined method for the preparation of gelatin embedded brains and simplified organization of sections for serial reconstructions

Liu A, Aoki S, Wickens J (2017) A streamlined method for the preparation of gelatin embedded brains and simplified organization of sections for serial reconstructions. Bio-protocol 7(22):e2610.. doi: 10.21769/BioProtoc.2610 Related Products: Anti-ChAT-SAP (Cat. #IT-42)

A streamlined method for the preparation of gelatin embedded brains and simplified organization of sections for serial reconstructions Read More »

Directed differentiation of periocular mesenchyme from human embryonic stem cells

Lovatt M, Yam GH-F, Peh GS, Colman A, Dunn NR, Mehta JS (2018) Directed differentiation of periocular mesenchyme from human embryonic stem cells. Differentiation 99:62-69. doi: 10.1016/j.diff.2017.11.003 PMID: 29239730 Objective: Pluripotent stem cells are attractive sources of cells for regenerative medicine, because large numbers of therapeutically useful cells can be generated. However, a detailed understanding

Directed differentiation of periocular mesenchyme from human embryonic stem cells Read More »

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