World Alzheimer’s Month – Latest publications

Cat. #IT-01  192-IgG-SAP

Long-term potentiation in the hippocampal CA3 to CA1 synapses may be induced in vivo by activation of septal cholinergic inputs. Dobryakova, Y. V., M. Y. Stepanichev, V. A. Markevich and A. P. Bolshakov (2020).  Int J Neurosci: 1-9.

Intracerebroventricular Administration of 192IgG-Saporin Alters the State of Microglia in the Neocortex. Volobueva, M. N., Y. V. Dobryakova, A. O. Manolova, M. Y. Stepanichev, A. A. Kvichansky, N. V. Gulyaeva, V. A. Markevich and A. P. Bolshakov (2020). Neurochem J 14(1): 37-42.

Cat. #IT-42  Anti-ChAT-SAP

Striatal cholinergic interneurons exert inhibition on competing default behaviors controlled by the nucleus accumbens and dorsolateral striatum. Ashkenazi, S. L., B. Polis, O. David and G. Morris (2020). Eur J Neurosci(FENS Abstract).

An acetylcholine-dopamine interaction in the nucleus accumbens and its involvement in ethanol’s dopamine-releasing effect. Loftén, A., L. Adermark, M. Ericson and B. Söderpalm (2020). Addict Biol: e12959.

Cat. #IT-01  192-IgG-SAP • Cat. #IT-16  mu p75-SAP

Identification of Multiple Targets in the Fight against Alzheimer’s Disease. Frontiers Media SA. Giannoni, P., S. Fossati, S. Claeysen and E. Marcello (2020).  “A collection of 20 articles that depict a broad representation of the most impactful advances in Alzheimer’s disease (AD) comprehension and therapeutic openings.”

#IT-02  OX7-SAP

Reversal of Object Recognition Memory Deficit in Perirhinal Cortex-Lesioned Rats and Primates and in Rodent Models of Aging and Alzheimer’s Diseases. Masmudi-Martín, M., I. Navarro-Lobato, M. F. López-Aranda, P. G. F. Browning, A.-M. Simón, J. F. López-Téllez, I. Jiménez-Recuerda, E. Martín-Montañez, A. Pérez-Mediavilla, D. Frechilla, M. G. Baxter and Z. U. Khan (2020). Neuroscience.

BETA Product  Urotensin-II-SAP

Cholinergic basal forebrain degeneration due to obstructive sleep apnoea increases Alzheimer’s pathology in mice. Qian, L., L. Kasas, M. R. Milne, O. Rawashdeh, N. Marks, A. Sharma, M. C. Bellingham and E. J. Coulson (2020).  bioRxiv: 2020.2003.2012.989848.

Saporin from Saponaria officinalis as a Tool for Experimental Research, Modeling, and Therapy in Neuroscience. Bolshakov AP, Stepanichev MY, Dobryakova YV, Spivak, YS, Markevich, VA (2020). Toxins (Basel), 12 (9):2020/08/29. 

The authors present a review of studies where saporin-based conjugates were used to analyze cell mechanisms of sleep, general anesthesia, epilepsy, pain, and development of Parkinson’s and Alzheimer’s diseases. 

Visit the ATS website to see tables of featured Saporin products:

Antibody-Saporin Conjugates (able to be retrogradely transported)

Peptide-Saporin Conjugates (NOT retrogradely transported)