Antibody-Saporin Conjugates (able to be retrogradely transported)
| Saporin Conjugate(s) | Molecular Target | Cell Subpopulation Killed | References |
|---|---|---|---|
| 192-IgG-SAP (192-Saporin) | Nerve growth factor receptor (NGFR), p75NTR | Rat cholinergic forebrain neurons Upper cervical ganglion | Cat. #IT-01 |
| Anti-ChAT-SAP (ChAT-SAP) | Choline acetyltransferase (ChAT) | Cholinergic interneurons of dorsal striatum | Cat. #IT-42 |
| Anti-DAT-SAP (DAT-SAP) | Dopamine Transporter (DAT) | Dopaminergic neurons Parkinson’s disease Model | Cat. #IT-25 |
| Anti-DBH-SAP (DSAP) | Dopamine beta hydroxylase (DBH) | Locus coeruleus/subcoeruleus Alzheimer’s disease Model | Cat. #IT-03 |
| Anti-GAT1-SAP (GAT1-SAP) | GABA transporter 1 (GAT1, slc6a1) | GABAergic neurons | Cat. #IT-32 |
| Anti-SERT-SAP | Serotonin Re-uptake Transporter (SERT) 5-HT | Amygdala-projecting neurons in the dorsal raphe nucleus Anterior hypothalamus | Cat. #IT-23 |
| Anti-vGAT-SAP (vGAT-SAP) | Vesicular GABA transporter (VGAT) | GABAergic neurons | Cat. #IT-71 |
| Mac1-SAP | CD11b, alpha subunit of Mac1 receptor (CR3) | Macrophages | Cat. #IT-06 |
| ME20.4-SAP | Nerve growth factor receptor (NGFR), p75NTR | Cholinergic forebrain neurons Upper cervical ganglion | Cat. #IT-15 |
| mu p75-SAP | Nerve growth factor receptor (NGFR), p75NTR | Mouse cholinergic forebrain neurons Upper cervical ganglion | Cat. #IT-16 |
Lectin-Saporin Conjugates (able to be retrogradely transported)
| Saporin Conjugate(s) | Molecular Target | Cell Subpopulation Killed | References |
|---|---|---|---|
| Cholera toxin B-SAP (CTB-SAP) | GM1-ganglioside | Majority of CNS neurons | Cat. #IT-14 |
| Isolectin B4-SAP (IB4-SAP) | Alpha-D- galactopyranoside residues | c-fiber nociceptor neurons | Cat. #IT-10 |
Peptide-Saporin Conjugates (NOT retrogradely transported)
| Saporin Conjugate(s) | Molecular Target | Cell Subpopulation Killed | References |
|---|---|---|---|
| Bombesin-SAP | Bombesin receptors (NMBR, GRPR, and BRS3) | GPRP-positive interneurons in the hippocampus and neocortex Neurons in the superficial dorsal horn of the spinal cord | Cat. #IT-40 |
| CCK-SAP | Cholecystokinin (CCK) Receptor | Widely distributed in the central nervous system and gastrointestinal tract | Cat. #IT-31 |
| CRF-SAP | Majority of CNS neurons | Cat. #IT-13 | |
| Galanin-SAP | Somatostatin-positive interneurons Neurons in globus pallidus and thalamus | Cat. #IT-34 | |
| Neurokinin B-SAP (NKB-SAP, NK3-SAP) | NKB Receptor (NK3) | Hypothalamic arcuate nucleus | Cat. #IT-63 |
| NPY-SAP | Majority of CNS neurons | Cat. #IT-28 | |
| Orexin-SAP (Hypocretin2-SAP, HCRT2-SAP, Orexin-B-SAP) | Majority of CNS neurons | Cat. #IT-20 | |
| Oxytocin-SAP | Somatostatin-positive interneurons Some pyramidal neurons on the hippocampus Neocortex, mossy cells in the dentate gyrus | Cat. #IT-46 | |
| Stable Substance P-SAP (SSP-SAP) | Neurokinin 1 receptor (NK1R) | Interneurons of hippocampus & neocortex Spinal cord lamina I neurons | Cat. #IT-11 |