Featured Saporin Conjugates

Antibody-Saporin Conjugates (able to be retrogradely transported)

Saporin Conjugate(s)Molecular TargetCell Subpopulation KilledReferences
192-IgG-SAP
(192-Saporin)
Nerve growth factor
receptor (NGFR),
p75NTR
Rat cholinergic forebrain neurons
Upper cervical ganglion
Cat. #IT-01
Anti-ChAT-SAP
(ChAT-SAP)
Choline
acetyltransferase
(ChAT)
Cholinergic interneurons of
dorsal striatum
Cat. #IT-42
Anti-DAT-SAP
(DAT-SAP)
Dopamine Transporter
(DAT)
Dopaminergic neurons
Parkinson’s disease Model
Cat. #IT-25
Anti-DBH-SAP
(DSAP)
Dopamine beta
hydroxylase (DBH)
Locus coeruleus/subcoeruleus
Alzheimer’s disease Model
Cat. #IT-03
Anti-GAT1-SAP
(GAT1-SAP)
GABA transporter 1
(GAT1, slc6a1)
GABAergic neuronsCat. #IT-32
Anti-SERT-SAPSerotonin Re-uptake
Transporter (SERT) 5-HT
Amygdala-projecting neurons
in the dorsal raphe nucleus
Anterior hypothalamus
Cat. #IT-23
Anti-vGAT-SAP
(vGAT-SAP)
Vesicular GABA
transporter (VGAT)
GABAergic neuronsCat. #IT-71
Mac1-SAPCD11b, alpha subunit
of Mac1 receptor (CR3)
MacrophagesCat. #IT-06
ME20.4-SAPNerve growth factor
receptor (NGFR),
p75NTR
Cholinergic forebrain neurons
Upper cervical ganglion
Cat. #IT-15
mu p75-SAPNerve growth factor
receptor (NGFR),
p75NTR
Mouse cholinergic forebrain
neurons
Upper cervical ganglion
Cat. #IT-16


Lectin-Saporin Conjugates (able to be retrogradely transported)

Saporin Conjugate(s)Molecular TargetCell Subpopulation KilledReferences
Cholera toxin B-SAP
(CTB-SAP)
GM1-gangliosideMajority of CNS neuronsCat. #IT-14
Isolectin B4-SAP
(IB4-SAP)
Alpha-D-
galactopyranoside
residues
c-fiber nociceptor neuronsCat. #IT-10


Peptide-Saporin Conjugates (NOT retrogradely transported)

Saporin Conjugate(s)Molecular TargetCell Subpopulation KilledReferences
Bombesin-SAPBombesin receptors
(NMBR, GRPR, and
BRS3)
GPRP-positive interneurons in
the hippocampus and
neocortex
Neurons in the superficial
dorsal horn of the spinal cord
Cat. #IT-40
CCK-SAPCholecystokinin (CCK) ReceptorWidely distributed in the
central nervous system and
gastrointestinal tract
Cat. #IT-31
CRF-SAPMajority of CNS neuronsCat. #IT-13
Galanin-SAPSomatostatin-positive
interneurons
Neurons in globus pallidus and
thalamus
Cat. #IT-34
Neurokinin B-SAP
(NKB-SAP, NK3-SAP)
NKB Receptor (NK3)Hypothalamic arcuate nucleusCat. #IT-63
NPY-SAPMajority of CNS neuronsCat. #IT-28
Orexin-SAP
(Hypocretin2-SAP,
HCRT2-SAP, Orexin-B-SAP)
Majority of CNS neuronsCat. #IT-20
Oxytocin-SAPSomatostatin-positive
interneurons
Some pyramidal neurons on
the hippocampus
Neocortex, mossy cells in the
dentate gyrus
Cat. #IT-46
Stable Substance P-SAP
(SSP-SAP)
Neurokinin 1 receptor
(NK1R)
Interneurons of hippocampus
& neocortex
Spinal cord lamina I neurons
Cat. #IT-11

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