13q1

Targeting Trends 2013 Newsletter

Read the 2013 Newsletters and recent scientific references 2013, issue 1: Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology / by F LaPlante / featuring Anti-ChAT-SAP (Cat. #IT-42), Rabbit IgG-SAP (Cat. #IT-35) SFN Poster of the Year Targeting Tools: Anti-ChAT-SAP (Cat.#IT-42) 2013, issue 2: Antibodies to glycosphingolipids: An attractive tool …

Targeting Trends 2013 Newsletter Read More »

Targeting Tools: Anti-ChAT-SAP

Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both peripheral and central nervous systems. Dysfuntion of cholinergic neurons underlies aspects of clinical symptoms found in neurological and psychiatric disorders such as Alzheimer’s disease, Down and …

Targeting Tools: Anti-ChAT-SAP Read More »

Cover Article: Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology

Contributed by François LaPlante. Dept of Psychiatry, McGill University, Montréal, QC, Canada A post-mortem reduction in the density of cholinergic interneurons in the ventral striatum or nucleus accumbens (N.Acc.) has been reported in schizophrenic brains.[1,2] In this region the cholinergic interneurons interact anatomically and functionally with the dopaminergic nerve terminals notably to dampen the effects …

Cover Article: Role of cholinergic neurons in the nucleus accumbens and their involvement in schizophrenic pathology Read More »