12q3

Targeting Trends Newsletter 12q3

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights FENS-Barcelona; Spring Brain Conference (page 2) LD50 of saporin immunotoxins in mice; Antagonists vs. Targeted Toxins (page 5) Teaser Winners (page 5) Mac-1-SAP; Anti-GST; Anti-SERT-SAP …

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Targeting Tools: Mac-1-SAP

The Mac-1-SAP targeted toxins recognize Mac-1-positive (CD11b) cells in mouse/human (Cat. #IT-06) or in rat (Cat. #IT-33). The toxin is excellent for removing contaminating macrophages from primary cultures. Elimination of macrophages in vivo is useful to determine their role(s) in autoimmune diseases and in degenerative diseases such as Alzheimer’s. Both toxins are extremely potent, with …

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Targeting Tools: Anti-GST

The Glutathione S-Transferase (GST) family of enzymes contains cytosolic, mitochondrial, and microsomal proteins that are capable of multiple reactions with a multitude of substrates, both endogenous and xenobiotic. GST catalyzes the conjugation of reduced glutathione which is useful in the detoxification of endogenous compounds such as peroxidized lipids, as well as the metabolism of xenobiotics. …

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Targeting Tools: Anti-SERT-SAP

Anti-SERT-SAP (Cat. #IT-23) utilizes a monoclonal antibody to the fourth extracellular domain of the serotonin re-uptake transporter (SERT). SERT is the major determinant of serotonin inactivation following release at synapses, is the site of action for many tricyclic antidepressants and the SSRIs (serotonin-selective reuptake inhibitors), and is also targeted by a number of psychostimulants including …

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Targeting Topics 12q3

C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats. Abbott SB, Kanbar R, Bochorishvili G, Coates MB, Stornetta RL, Guyenet PG. J Physiol 590(12):2897-2915, 2012. C1 neurons are known to activate sympathetic tone and stimulate the hypothalamic-pituitary-adrenal axis. C1 activation is also reported to inhibit locus coeruleus (LC) neurons. …

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Cover Article: A pivotal role of lumbar spinothalamic cells in regulation of ejaculation via intraspinal connections

Contributed by Lique M. Coolen, University of Michigan Introduction from Dr. Lappi: An article by Lique Coolen’s group[5] was the 1000th article in PubMed in response to the search word ‘saporin.’ Dr. Coolen has graciously agreed to describe the latest in her fascinating work. Male sexual behavior consists of many different aspects, with ejaculation being …

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