10q4

Targeting Trends Newsletter 10q4

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights $3 Million Award (page 2) Teaser Winners (page 2) Anti-DBH-SAP tracer (page 5) GAT1-SAP (page 7) Complete and Submit the Targeting Teaser online! Targeted Ablation …

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Targeting Tools: GAT1-SAP

GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving g-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy, …

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Targeting Topics 10q4

Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat Joseph EK, Levine JD Neuroscience 171(1):344-350, 2010. In this work the authors analyzed nociceptor populations mediating mechanical hyperalgesia in the rat. Rats received 3.2 µg of IB4-SAP (Cat. #IT-10) into the subarachnoid space between the L4 and L5 vertebrae. Hyperalgesia due to the …

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Cover Article: Targeted Ablation of Sympathetic Neurons Reduces Ventricular Arrhythmias and Autonomic Dysreflexia

Contributed by Heidi L. Lujan and Stephen E. DiCarloDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 Excessive sympathetic activity is responsible for, and/or contributes to, the morbidity and mortality associated with cardiovascular diseases (e.g. hypertension, stroke, heart failure, ischemic heart disease, ventricular arrhythmias). For example, myocardial ischemia provokes a powerful reflex …

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