10q4

Targeting Trends 2010 Newsletter

2010, issue 1: Deletion of NPY/AGRP and POMC Neurons in the Arcuate Nucleus by Leptin-Saporin Produces Hyperphagia, Obesity and Changes in Diurnal Feeding Patterns in Rats / by Li AJ, Wang Q, Dinh TT, Ritter S / featuring Leptin-SAP (Cat. #IT-47) and Blank-SAP (Cat. #IT-21) SFN Poster of the Year Targeting Talk: Product Questions Targeting Tools: Leptin-SAP (Cat. #IT-47) …

Targeting Trends 2010 Newsletter Read More »

Targeting Tools: GAT1-SAP

GAT-1 is a sodium-coupled neurotransmitter transporter responsible for moving g-aminobutyric acid (GABA) across cell membranes. GABA is the predominant inhibitory neurotransmitter in the mammalian central nervous system. GAT-1 is widely distributed in both the central and peripheral nervous systems. GAT-1 and GABA are present in numerous neuronal pathways, some of which are implicated in epilepsy, …

Targeting Tools: GAT1-SAP Read More »

Targeting Topics 10q4

Mu and delta opioid receptors on nociceptors attenuate mechanical hyperalgesia in rat Joseph EK, Levine JD Neuroscience 171(1):344-350, 2010. In this work the authors analyzed nociceptor populations mediating mechanical hyperalgesia in the rat. Rats received 3.2 µg of IB4-SAP (Cat. #IT-10) into the subarachnoid space between the L4 and L5 vertebrae. Hyperalgesia due to the …

Targeting Topics 10q4 Read More »

Cover Article: Targeted Ablation of Sympathetic Neurons Reduces Ventricular Arrhythmias and Autonomic Dysreflexia

Contributed by Heidi L. Lujan and Stephen E. DiCarloDepartment of Physiology, Wayne State University School of Medicine, Detroit, MI 48201 Excessive sympathetic activity is responsible for, and/or contributes to, the morbidity and mortality associated with cardiovascular diseases (e.g. hypertension, stroke, heart failure, ischemic heart disease, ventricular arrhythmias). For example, myocardial ischemia provokes a powerful reflex …

Cover Article: Targeted Ablation of Sympathetic Neurons Reduces Ventricular Arrhythmias and Autonomic Dysreflexia Read More »