08q2

Targeting Trends Newsletter 08q2

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights ATS Licenses SP-SAP (page 2) Upcoming Events (page 2) Teaser Winners (page 4) mu p75-SAP, WBLyse™, CFSE (page 7) Complete and Submit the Targeting Teaser …

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Targeting Tools: mu p75-SAP

In 2004, ATS re-designed the anti-murine p75-SAP targeted toxin (mu p75-SAP, Cat. #IT-16) and produced a conjugate that is much more potent in our in vitro cell cytotoxicity assays. Previously, we used a rat monoclonal antibody. This antibody had been outperformed by our rabbit polyclonal (Cat. #AB- N01), in several assays, especially flow cytometry analysis …

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Targeting Topics 08q2

Septal grafts restore cognitive abilities and amyloid precursor protein metabolism. Aztiria E, Cataudella T, Spampinato S, Leanza G. Neurobiol Aging 30(10):1614-1625, 2009. Although cholinergic loss and the presence of b-amyloid plaques are well documented in Alzheimer’s disease, it is unknown whether restoration of regulatory cholinergic inputs affects in vivo b-amyloid precursor protein (APP). 5 µg …

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Cover Article: Selective lesion of basal forebrain cholinergic neurons in mice with the mu p75-saporin immunotoxin: Neuroanatomy and behavior

Contributed by Pierre-Henri Moreau, Brigitte Cosquer, Hélène Jeltsch, Jean-Christophe Cassel, Chantal MathisLaboratoire d’Imagerie et de Neurosciences Cognitives, UMR7191 CNRS,Equipe de Neurobiologie Cognitive et Comportementale, Université Louis Pasteur,IFR 37 de Neurosciences, GDR 2905 CNRS, 12 rue Goethe, 67000 Strasbourg, France The basal forebrain cholinergic neurons (BFCNs) are dramatically affected in several neurodegenerative diseases such as Alzheimer’s …

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