08q2

Targeting Trends 2008 Newsletter

Read the 2008 Newsletters 2008, issue 1: Role of medial septal GABAergic neurons in learning and extinction: Effects of the novel GABA immunotoxin GAT1-SAP / by Pang KCH, Jiao X, Servatius RJ / featuring GAT1-SAP (Cat. #IT-32) SFN Poster of the Year Targeting Talk: Secondary Conjugate Protocol, Reducing Agents Targeting Tools: New Products Stimulate Instead …

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Targeting Tools: mu p75-SAP

In 2004, ATS re-designed the anti-murine p75-SAP targeted toxin (mu p75-SAP, Cat. #IT-16) and produced a conjugate that is much more potent in our in vitro cell cytotoxicity assays. Previously, we used a rat monoclonal antibody. This antibody had been outperformed by our rabbit polyclonal (Cat. #AB- N01), in several assays, especially flow cytometry analysis …

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Targeting Topics 08q2

Septal grafts restore cognitive abilities and amyloid precursor protein metabolism. Aztiria E, Cataudella T, Spampinato S, Leanza G. Neurobiol Aging 30(10):1614-1625, 2009. Although cholinergic loss and the presence of b-amyloid plaques are well documented in Alzheimer’s disease, it is unknown whether restoration of regulatory cholinergic inputs affects in vivo b-amyloid precursor protein (APP). 5 µg …

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Cover Article: Selective lesion of basal forebrain cholinergic neurons in mice with the mu p75-saporin immunotoxin: Neuroanatomy and behavior

Contributed by Pierre-Henri Moreau, Brigitte Cosquer, Hélène Jeltsch, Jean-Christophe Cassel, Chantal MathisLaboratoire d’Imagerie et de Neurosciences Cognitives, UMR7191 CNRS,Equipe de Neurobiologie Cognitive et Comportementale, Université Louis Pasteur,IFR 37 de Neurosciences, GDR 2905 CNRS, 12 rue Goethe, 67000 Strasbourg, France The basal forebrain cholinergic neurons (BFCNs) are dramatically affected in several neurodegenerative diseases such as Alzheimer’s …

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