Tag Archives: 07q3

Targeting Trends Newsletter 07q3

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights New Targets: Claustrum (page 2) Teaser Winners (page 2) Flow Cytometry Services (page 6) Anti-CD22 and Anti-CD22-SAP (page 7)

Targeting Talk: Disposal, Sterilization, Intrastriatal Administration, and Activation

Your targeted toxin data sheet gives the following instruction for disposal: “Care in disposal is mandatory; autoclaving or exposure to 1 M sodium hydroxide will inactivate the material. All labware that comes into contact with this material should be likewise treated.” I am wondering if I can deactivate saporin by using 10% bleach or if […]

Targeting Topics 07q3

Cholinergic modulation of spindle bursts in the neonatal rat visual cortex in vivo Hanganu IL, Staiger JF, Ben-Ari Y, Khazipov R J Neurosci 27(21):5694-5705, 2007. The authors investigated the relationship between cholinergic drive and spindle burst oscillation driven by retinal waves. 0.5 µl of 0.2-µg/µl 192-IgG-SAP (Cat. #IT-01) was injected into both ventricles of rat […]

IT-07

Targeted Therapy for Chronic Pain

In 1997, SP-SAP (a chemical conjugate of Substance P and the ribosome-inactivating protein saporin) was created to eliminate Substance P receptor (SPR) neurons that propagate the signal for chronic pain. ATS has successfully completed preclinical studies, safety tests in animal models and a GLP toxicology study in rat, funded both internally and by the National […]