2007, issue 1: Cholinergic Immunolesioning Produced Tangle-like Inclusions in TgCRND8 Brain / by Chauhan N / featuring mu p75-SAP (Cat. #IT-16) SFN Poster of the Year Targeting Talk: Targeted Toxin Controls Targeting Tools Anti-Pseudomonas aeurginosa (Cat. #AB-T057) Anti-Conjugated Glutathione (Cat. #AB-T01) Anti-Conjugated Acetylcholine (Cat. #AB-T02) Anti-Conjugated Dopamine (Cat. #AB-T11) Anti-CRH/CRF (Cat. #AB-02) Anti-basic FGF (Cat. #AB-07, Cat. #AB-08) …
Anti-Conjugated Glutathione, Cat. #AB-T01 Glutathione is a small protein composed of three amino acids: cysteine, glutamic acid, and glycine. The primary biological function of glutathione is to act as a non-enzymatic reducing agent. Glutathione is also involved in detoxification. Anti-Conjugated Glutathione targets conjugated glutathione which is created by fixation in glutaraldehyde. Applications include ELISA and …
Anti-Conjugated Acetylcholine, Cat. #AB-T02 Acetylcholine is a neurotransmitter found in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Anti-Conjugated Acetylcholine targets conjugated choline-glutaric acid which is created by fixation in glutaraldehyde. Applications include ELISA and immunohistochemistry.
Anti-Conjugated Dopamine, Cat. #AB-T11 Dopamine is a neurotransmitter found in various areas of the central and peripheral nervous system. Dopamine and its agonists play an important role in cardiovascular, renal, hormonal, and central nervous system regulation. Anti-Conjugated Dopamine targets conjugated dopamine which is created by fixation in glutaraldehyde. Applications include ELISA, immunocytochemistry, immunohistochemistry, and immunoblotting.
Anti-CRH/CRF, Cat. #AB-02 Corticotropin-releasing hormone/factor (CRH/CRF) is the principal neuropeptide involved in regulating the stress response. It stimulates ACTH release from the pituitary gland. When centrally administered to animals it produces somatic changes analogous to those seen in both depression and anxiety. In humans, it is capable of reproducing the hormonal changes which are characteristically …
Anti-basic FGF (FGF-2), Cat. #AB-07, Cat. #AB-08 Basic Fibroblast Growth Factor (FGF-2) is a 155-amino-acid protein (154 amino acids in rat) that has wide-ranging effects in a variety of systems. FGF-2 (also known as basic FGF) can induce proliferation of fibroblasts, endothelial cells, chondrocytes, smooth muscle cells, melanocytes, and other cell types. FGF-2 also has …
Anti-Pseudomonas aeruginosa, Cat. #AB-T057 Pseudomonas aeruginosa is a Gram-negative bacterium that causes many infections, particularly in people with cystic fibrosis, burn victims, individuals with cancer and others who are immunosuppressed. This bacterium is studied by scientists not only because of its ability to cause disease and resist antibiotics, but also its metabolic capability and environmental …
Your targeted toxin kits come with different controls. I’m not sure of the best way to use them. For example, with the anti-SERT-SAP kit (Cat. # KIT-23) there is included unconjugated antibody, unconjugated saporin, and a control conjugate, mouse IgG-SAP. Should I use them all in the same experiment or for different purposes? Yes, perhaps …
Ablation of NK1 receptor bearing neurons in the nucleus of the solitary tract blunts cardiovascular reflexes in awake rats. Abdala AP, Schoorlemmer GH, Colombari E. Brain Res 1119(1):165-173, 2006. Cardiovascular function is largely controlled by the nucleus of the tractus solitarius (NTS). This work focuses on the baroreflex, cardiopulmonary chemoreflex, and arterial chemoreflex. Rats were …
Contributed by Neelima Chauhan, Dept Anesthes/Anat & Cell Bio, Univ Illinois-Chicago;J. Brown VA Med Ctr Chicago, Chicago, IL and winner of the 2006 SfN Poster Award for work using ATS products. Today’s Alzheimer’s disease (AD) research lacks a “complete” model that would represent both plaque and tangle pathology together with correlative memory deficits. The currently …