Tag Archives: 05q2

Targeting Trends Newsletter 05q2

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights SP-SAP therapeutic update(page 2) Teaser Winners (page 2) Control toxins (page 7)

Targeting Tools: Control Immunotoxins

One of the most important features of the Advanced Targeting Systems product line is the availability of control toxins that allow the researcher to fully evaluate results of the treatment of cells or animals with targeted toxins. For instance, anti-DBH-SAP is targeted with a mouse monoclonal antibody. Its control partner is mouse IgG-SAP, that is, […]

Targeting Talk: Cytotoxicity of Unbound Saporin

We are re-examining some data collected using an immunotoxin not prepared by your company (VChAT-sap). Our results in vivo indicated that there were non-specific effects although the creators claimed it was specific. We ran a Western Blot and determined that about half the saporin was not bound to the antibody. This may have been the […]

Targeting Topics 05q2

Basomedial hypothalamic injections of neuropeptide Y conjugated to saporin selectively disrupt hypothalamic controls of food intake. Bugarith K, Dinh TT, Li AJ, Speth RC, Ritter S. Endocrinology 146(3):1179-1191, 2005. Neurons in the arcuate nucleus (ARC) that coexpress neuropeptide-Y (NPY) and Agouti gene-related protein may be involved in glucoprivic feeding. The authors investigated the use of […]

SP-SAP: How It’s Different From Substance P Antagonists

As most of you know, SP-SAP is a potential therapeutic that ATS is developing for use in the elimination of chronic pain. For the past seven years, preclinical studies have been carried out in the rat, safety and dosing studies completed in the dog and the first of two toxicology studies has begun in the […]

Cover Article: Noradrenergic inputs to the medial amygdala originate in the A1 and A2 cells groups and release norepinephrine after mating stimulation sufficient to induce pseudopregnancy

Contributed by Lesley E. Northrop, Nicole Cameron and Mary Erskine, Department of Biology, Boston University The posterodorsal medial amygdala (MePD) is involved in processing the information from genito- sensory stimuli which is needed for mating-induced pseudopregnancy. The amygdala complex is known to be involved in memory storage and consolidation, processes known to be influenced by […]