2005, issue 1: IB4-SAP Prevents Axotomy-Induced Sprouting of Aß Fibers / by Pearson M / featuring IB4-SAP (Cat. #IT-10) ATS Seeks Strategic Partner for Chronic Pain Drug SFN Poster of the Year Targeting Talk: Effective Toxins Targeting Tools: Anti-ChAT (Cat. #AB-N34 and AB-N34AP) 2005, issue 2: Noradrenergic inputs to the medial amygdala originate in the A1 and …
ATS is pleased to present a polyclonal antibody specific for ChAT protein. Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both the peripheral and central nervous systems. Dysfunction of cholinergic neurons underlies aspects of clinical …
Basomedial hypothalamic injections of neuropeptide Y conjugated to saporin selectively disrupt hypothalamic controls of food intake. Bugarith K, Dinh TT, Li AJ, Speth RC, Ritter S. Endocrinology 146(3):1179-1191, 2005. The authors examined the effect of 48 ng injections of NPY-SAP (Cat. #IT-28) into the basomedial hypothalamus (BMH) on glucoprivic feeding in rats. While there was …
Toxicology studies with the potential chronic pain therapeutic, SP-SAP (Substance P-Saporin) are continuing successfully. The second study will be initiated in a few months and ATS is diligently pursuing a pharmaceutical partner that can quickly bring the drug to clinical trials in humans. With the recent news of the undesirable side effects of such pain …
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Contributed by ATS’s 2004 Society for Neuroscience Poster of the Year Award Winner:Michelle Pearson, Purdue Pharma, Discovery Research, 6 Cedar Brook Drive, Cranbury NJ 08540 Neuropathic pain results in hyperalgesia and allodynia. It has been proposed that sprouting of myelinated touch-responsive Aβ-fibers into the innervation territory of pain-sensitive C-fibers in the spinal cord contributes to …
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