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Targeting Tools: Anti-ChAT

ATS is pleased to present a polyclonal antibody specific for ChAT protein. Choline acetyltransferase (ChAT) catalyzes the synthesis of the neurotransmitter acetylcholine (ACh) from choline and acetyl-CoA in cholinergic neurons. ChAT serves as a specific marker for cholinergic neurons in both the peripheral and central nervous systems. Dysfunction of cholinergic neurons underlies aspects of clinical

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ATS Seeks Strategic Partner for Chronic Pain Drug

Toxicology studies with the potential chronic pain therapeutic, SP-SAP (Substance P-Saporin) are continuing successfully. The second study will be initiated in a few months and ATS is diligently pursuing a pharmaceutical partner that can quickly bring the drug to clinical trials in humans. With the recent news of the undesirable side effects of such pain

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Cover Article: IB4-SAP Prevents Axotomy-Induced Sprouting of Aß Fibers

Contributed by ATS’s 2004 Society for Neuroscience Poster of the Year Award Winner:Michelle Pearson, Purdue Pharma, Discovery Research, 6 Cedar Brook Drive, Cranbury NJ 08540 Neuropathic pain results in hyperalgesia and allodynia. It has been proposed that sprouting of myelinated touch-responsive Aβ-fibers into the innervation territory of pain-sensitive C-fibers in the spinal cord contributes to

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