04q4

Targeting Trends Newsletter 04q4

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights An afternoon in the park… (page 2) Venice Watercolor (page 2) SfN meeting in San Diego (page 6) CCK-SAP, NPY-SAP, Anti-M-ZAP, and new antibodies (page …

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Targeting Tools: CCK-SAP

CCK-SAP (Cat. #IT-31) This new targeted toxin is a chemical conjugate of sulfonated cholecystokinin (CCK) and the ribosome-inactivating protein, saporin. CCK is widely distributed in the central nervous system and the gastrointestinal tract. CCK-SAP is an effective tool to study eating disorders and pain transmission. CCK-SAP eliminates cells recognizing sulfonated CCK. All other cells are …

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Targeting Tools: NPY-SAP

NPY-SAP (Cat. #IT-28) NPY-SAP is a chemical conjugate of neuropeptide Y (NPY) and the ribosome-inactivating protein, saporin. NPY is the most abundant neuropeptide in the brain and is involved in many processes from prenatal to mature animals. It promotes the proliferation of postnatal neuronal precursor cells and exhibits a diverse range of important physiologic activities, …

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Targeting Tools: Anti-M-ZAP

Anti-M-ZAP (Cat. #IT-30) Anti-M-ZAP is another product in the line of second immunotoxins. Second immunotoxins are conjugations of a secondary antibody to the ribosome-inactivating protein, saporin. The second immunotoxin uses the secondary antibody to “piggyback” onto YOUR primary antibody in order to evaluate the ability of the primary antibody to internalize. Anti-M-ZAP is a chemical …

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Targeting Talk: Effective Toxins

Why do your directions for SSP-SAP (Cat. #IT-11) state that it is to be used within hours after dissolution? To my knowledge, both proteins and peptides are stable in clean solution. In fact, the two components of SSP-SAP (Stable Substance P and Saporin) are quite stable. However, we have found that many things happen in …

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Targeting Topics 04q4

Decreased neurogenesis after cholinergic forebrain lesion in the adult rat. Cooper-Kuhn CM, Winkler J, Kuhn HG. J Neurosci Res 77(2):155-165, 2004. Adult mammalian brains can produce new neurons, mainly in two areas: the interconnected system of the lateral ventricle and the olfactory bulb, and the dentate gyrus of the hippocampus. The authors used a 3.5 …

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Cover Article: Effects of IB4-SAP on Bladder Overactivity

Contributed by Dr. Naoki Yoshimura, Dept Urology/Pharmacology, Univ Pittsburgh School of Medicine, Pittsburgh PA 15213.Dr. Yoshimura summarizes his work with IB4-SAP. A complete report was published in Eur J Neurosci 20(2):474-482, 2004. It has been demonstrated that hyperexcitability of C-fibers in bladder afferent pathways can contribute to bladder overactivity and/or bladder pain under pathological conditions …

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