04q1

Targeting Trends 2004 Newsletter

2004, issue 1: Cholinergic Deafferentation of the Entorhinal Cortex Impairs Working Memory for Novel, but not Familiar Stimuli in a Delayed Non-Match to Sample (DNMS) Task / by McGaughy J / featuring 192-IgG-SAP (Cat. #IT-01) ATS Gets New Facility for SP-SAP Production SFN Poster of the Year Targeting Talk: Not the Right Stuff Targeting Tools: …

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Targeting Tools: Somatostatin Receptor Targeting

Advanced Targeting Systems is pleased to announce the availability of polyclonal antibodies to somatostatin receptor (SSTr) sub-types 1 and 4. SSTr1 antiserum, Cat. #AB-N19 SSTr1 affinity-purified, Cat. #AB-N20AP SSTr4 affinity-purified, Cat. #AB-N21AP Antibody to SSTr1 SSTr1 is a 391 amino acid G-protein-coupled receptor that contains three glycosylation sites and that is expressed in several areas …

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Targeting Talk: Not the Right Stuff

Are all lots of 192-Saporin (192-IgG-SAP, Cat. #IT-01) the same? There are variances from lot to lot, and Advanced Targeting Systems includes a cytotoxicity graph on the data sheet with each product comparing the current lot with previous lots. Chemicon International also sells immunotoxins, and used to distribute ATS products. However, since early 2002 (according …

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Targeting Topics 04q1

Does the release of acetylcholine in septal slices originate from intrinsic cholinergic neurons bearing p75(NTR) receptors? A study using 192 IgG-saporin lesions in rats. Birthelmer A, Lazaris A, Riegert C, Marques Pereira P, Koenig J, Jeltsch H, Jackisch R, Cassel JC. Neuroscience 122(4):1059-1071, 2003. The authors used 0.8 µg injections of 192-Saporin (Cat. #IT-01) into …

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Cover Article: Cholinergic Deafferentation of the Entorhinal Cortex Impairs Working Memory for Novel, but not Familiar Stimuli in a Delayed Non-Match to Sample (DNMS) Task.

Contributed by ATS’s 2003 Society for Neuroscience Poster of the Year Award Winner:Dr. Jill McGaughy, Boston University, 64 Cummington St., Boston, MA 02215 Muscarinic cholinergic receptor activation in entorhinal cortex (EC) activates intrinsic depolarizing membrane currents, which cause self-sustained spiking activity in single neurons.[1] This effect may underlie delay activity and match-dependent activity changes in …

Cover Article: Cholinergic Deafferentation of the Entorhinal Cortex Impairs Working Memory for Novel, but not Familiar Stimuli in a Delayed Non-Match to Sample (DNMS) Task. Read More »