03q3

Targeting Trends Newsletter 03q3

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Dr. Rania Siam joins ATS team (page 2) SP-SAP update (page 2) Dosing, Volume & Animal Care (page 5) Targeting Dopamine Transporter (page 7) Page …

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Targeting Tools: Targeting the Dopamine Transporter

Advanced Targeting Systems announces the availability of two monoclonal antibodies to the dopamine transporter (DAT). These antibodies have become a standard for work on DAT and have already played a prominent role in the characterization of the dopamine transporter. The two antibodies are rat monoclonals, so they can be excellent for multiple staining protocols. Anti-DAT-NT, Cat. …

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Targeting Topics 03q3

Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli. Vierck CJJ, Kline RH, Wiley RG. Neuroscience 119(1):223-232, 2003. Administration of SP-SAP (Cat. #IT-07) eliminates sensitization of nocifensive reflexes. The authors investigate whether SP-SAP elimination of neurokinin-1 receptor-expressing neurons in the lumbar spinal cord affects nociceptive sensitivity in general, or preferentially affects nociception dependent on …

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Cover Article: A New Immunotoxin for Targeting Dopaminergic Neurons

Targeting results with anti-DAT-SAP (Cat. #IT-25) shown in Figure 1 are reprinted by permission of Kluwer Academic/Plenum Publishers. The original was published in Cell Mol Neurobiol 23:839-850, 2003. Dopaminergic neurons are widely studied because of their role in one of the devastating diseases of old age, Parkinson’s. Lesioning studies using 6-hydroxydopamine or MPTP have been …

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