03q3

Targeting Trends 2003 Newsletter

Read the 2003 Newsletters 2003, issue 1: Deep Lumbar Neurons Control Ejaculation / by Truitt W / featuring SSP-SAP, Cat. #IT-11 SFN Poster of the Year SP-SAP as a Chronic Pain Therapeutic: An Update Targeting Talk: Custom Peptide-Saporin Conjugates Targeting Tools: Dermorphin-SAP (Cat. #IT-12) 2003, issue 2: Biotinylated targeting: A viable option? / featuring IB4-SAP (Cat. …

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Targeting Tools: Targeting the Dopamine Transporter

Advanced Targeting Systems announces the availability of two monoclonal antibodies to the dopamine transporter (DAT). These antibodies have become a standard for work on DAT and have already played a prominent role in the characterization of the dopamine transporter. The two antibodies are rat monoclonals, so they can be excellent for multiple staining protocols. Anti-DAT-NT, Cat. …

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Targeting Topics 03q3

Intrathecal substance p-saporin attenuates operant escape from nociceptive thermal stimuli. Vierck CJJ, Kline RH, Wiley RG. Neuroscience 119(1):223-232, 2003. Administration of SP-SAP (Cat. #IT-07) eliminates sensitization of nocifensive reflexes. The authors investigate whether SP-SAP elimination of neurokinin-1 receptor-expressing neurons in the lumbar spinal cord affects nociceptive sensitivity in general, or preferentially affects nociception dependent on …

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Cover Article: A New Immunotoxin for Targeting Dopaminergic Neurons

Targeting results with anti-DAT-SAP (Cat. #IT-25) shown in Figure 1 are reprinted by permission of Kluwer Academic/Plenum Publishers. The original was published in Cell Mol Neurobiol 23:839-850, 2003. Dopaminergic neurons are widely studied because of their role in one of the devastating diseases of old age, Parkinson’s. Lesioning studies using 6-hydroxydopamine or MPTP have been …

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