03q2

Targeting Trends Newsletter 03q2

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Funding Awarded (page 2) Retrograde Transport (page 5) Avidinylated-SAP (page 7) Page 1 Page 5 Page 2 Page 6 Page 3 Page 7 Page 4 …

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Targeting Tools: Avidinylated SAP

a chemical conjugate of avidin and the ribosome-inactivating protein, saporin Avidin is a glycoprotein found in egg white and in tissues of birds, reptiles, and amphibians. This protein is composed of four subunits, each of which can bind one molecule of biotin. Biotin, a 244-dalton vitamin found in tissue and blood, binds with high affinity to …

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Targeting Topics 03q2

Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2-saporin on sleep in Long-Evans rats. Gerashchenko D, Blanco-Centurion C, Greco MA, Shiromani PJ. Neuroscience 116(1):223-235, 2003. Recent data has linked narcolepsy to the loss of neurons containing the neuropeptide hypocretin, also known as orexin. The authors wished to investigate whether the variance in severity of narcolepsy …

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Funding Awarded for SBIR Phase II Grant

On February 1, 2003 ATS was awarded an $800,000 grant from the National Institutes of Health, National Institute of Mental Health. This three-year grant will support the creation of monoclonal antibodies to the extracellular domains of G protein-coupled receptors. These receptors play an important role in all aspects of human health, reflecting their widespread presence …

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Cover Article: Biotinylated targeting. A viable option?

For the IB4-SAP (Cat. #IT-10) illustration (Figure 1), our thanks to Christopher N. Honda, Ph.D., Associate Professor, Department of Neuroscience, University ofMinnesota, 6-145 Jackson Hall, 321 Church Street, Minneapolis, MN 55455 This issue of our quarterly newsletter addresses the use of biotinylated materials in targeting. ATS is now offering a biotinylation service (see p. 7) …

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