03q2

Targeting Trends 2003 Newsletter

2003, issue 1: Deep Lumbar Neurons Control Ejaculation / by Truitt W / featuring SSP-SAP, Cat. #IT-11 SFN Poster of the Year SP-SAP as a Chronic Pain Therapeutic: An Update Targeting Talk: Custom Peptide-Saporin Conjugates Targeting Tools: Dermorphin-SAP (Cat. #IT-12) 2003, issue 2: Biotinylated targeting: A viable option? / featuring IB4-SAP (Cat. #IT-10) Funding Awarded for …

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Targeting Tools: Avidinylated SAP

a chemical conjugate of avidin and the ribosome-inactivating protein, saporin Avidin is a glycoprotein found in egg white and in tissues of birds, reptiles, and amphibians. This protein is composed of four subunits, each of which can bind one molecule of biotin. Biotin, a 244-dalton vitamin found in tissue and blood, binds with high affinity to …

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Targeting Topics 03q2

Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2-saporin on sleep in Long-Evans rats. Gerashchenko D, Blanco-Centurion C, Greco MA, Shiromani PJ. Neuroscience 116(1):223-235, 2003. Recent data has linked narcolepsy to the loss of neurons containing the neuropeptide hypocretin, also known as orexin. The authors wished to investigate whether the variance in severity of narcolepsy …

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Funding Awarded for SBIR Phase II Grant

On February 1, 2003 ATS was awarded an $800,000 grant from the National Institutes of Health, National Institute of Mental Health. This three-year grant will support the creation of monoclonal antibodies to the extracellular domains of G protein-coupled receptors. These receptors play an important role in all aspects of human health, reflecting their widespread presence …

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Cover Article: Biotinylated targeting. A viable option?

For the IB4-SAP (Cat. #IT-10) illustration (Figure 1), our thanks to Christopher N. Honda, Ph.D., Associate Professor, Department of Neuroscience, University ofMinnesota, 6-145 Jackson Hall, 321 Church Street, Minneapolis, MN 55455 This issue of our quarterly newsletter addresses the use of biotinylated materials in targeting. ATS is now offering a biotinylation service (see p. 7) …

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