2003, issue 1: Deep Lumbar Neurons Control Ejaculation / by Truitt W / featuring SSP-SAP, Cat. #IT-11 SFN Poster of the Year SP-SAP as a Chronic Pain Therapeutic: An Update Targeting Talk: Custom Peptide-Saporin Conjugates Targeting Tools: Dermorphin-SAP (Cat. #IT-12) 2003, issue 2: Biotinylated targeting: A viable option? / featuring IB4-SAP (Cat. #IT-10) Funding Awarded for …
Even though it only became available recently, Dermorphin-SAP (Cat. #IT-12) has already begun to help researchers unlock the mysteries of brain function. Dermorphin-SAP is a chemical conjugate between an analog of the frog skin peptide dermorphin and the ribosome- inactivating protein saporin. Dermorphin, a peptide of seven amino acids characterized by Ersparmer and his colleagues,1 …
How do I know my peptide will work as a targeted toxin? There is a rich literature that demonstrates peptides can usher proteins that inhibit protein synthesis (such as saporin) into cells and result in cell death. Peptide ligands that bind to the cell surface (i.e., to their receptors) are internalized-in fact, often quite rapidly. …
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Basal forebrain cholinergic neurons are necessary for estrogen to enhance acquisition of a delayed matching-to-position T-maze task. Gibbs RB. Horm Behav 42(3):245-257, 2002. The author investigated the role of cholinergic neurons of the basal forebrain in cognitive function using a long-term hormone replacement model in rats. Septal infusions of either 1.0 μg or 0.22 μg …
Advanced Targeting Systems continues to search for funding to develop Substance P-Saporin (SP-SAP) as a chronic pain therapeutic. In May of last year we decided to seek venture capital funding and began traveling to make presentations to potential investors. The response from most everyone we spoke to was positive and they thought the potential of …
Contributed by William Truitt, PhD, Department of Cell Biology, Neurobiology, and Anatomy, Neuroscience Graduate Program, University of Cincinnati, College of Medicine, Post Office Box 670521, Cincinnati, OH 45267-0521, USA. Previously we demonstrated the existence of a spinothalamic pathway in the male rat where neural activation is specifically induced by ejaculation.1 This pathway includes the parvocellular …
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