Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Custom Conjugations (page 2) Abstracts from FENS (page 5) Abstracts from IASP (page 5) anti-SERT-SAP (page 7) Page 1 Page 5 Page 2 Page 6 …
Unilateral lesions of the cholinergic basal forebrain and fornix in one hemisphere and inferior temporal cortex in the opposite hemisphere produce severe learning impairments in rhesus monkeys. Easton A, Ridley RM, Baker HF, Gaffan D. Cereb Cortex 12(7):729-736, 2002. PMID: 12050084 The authors used a combination of basal forebrain lesioning using ME20.4-SAP (Cat. #IT-15) and …
How do I know my antibody will work in an immunotoxin? We recommend that you use one of our second immunotoxins (secondary conjugates) to test for specificity and internalization of your antibody. How much antibody do I need to provide for a custom conjugation? The required quantity is 8-15 mg of purified monoclonal antibody. How …
Targeting Talk: Custom Antibody-Saporin Conjugates Read More »
Contributed by Jean-Christophe Cassel, PhD, Laboratoire de Neurosciences Cognitives et Comportementales, UMR 7521 Université Louis Pasteur/CNRS, Strasbourg, France & Institut für Experimentelle und Klinische Pharmakologie und Toxikologie der Universität Freiburg, Neuropharmakologisches Labor, Freiburg, Germany. Dr. Cassel and colleagues are the authors of four publications released this quarter using 192-Saporin (Cat. #IT-01) Trying to understand how …
Cover Article: Does 192-IgG-Saporin or 5,7-DHT kill cognitive functions in the rat? Read More »
Advanced Targeting Systems announces the release of two reagents for immunological studies: Anti-Tac (Cat.# AB-18) – a monoclonal antibody to human CD25, the interleukin-2 receptor, and Anti-Tac-SAP (Cat.# IT-23) – the immunotoxin made by conjugation of anti-Tac to saporin. These reagents add to the growing list of ATS products for use in studies of the …