2001, issue 1: Immunolesioning: From Spinal Cord to Brain / by Schreihofer A / featuring Anti-DBH-SAP (Cat. #IT-03) Jennifer Martin wins “ATS Abstract of the Year Award” Targeting Talk: In vivo Use of Targeted Toxins Targeting Tools: IB4-SAP 2001, issue 2: Safety Studies Begin for Chronic Pain Therapeutic Targeting Talk: Suicide Transport and Immunolesioning Targeting Tools: Controls for …
Saporin is a 30 kDa protein isolated from the seeds of the plant Saponaria officinalis. This pleasant resident of the banks of Southern European streams has long been known for medicinal properties, mainly due to its saponins, detergents that reside especially in the roots of the plant and which give the plant its name. It …
Targeting Tools: Saporin – a ribosome-inactivating protein Read More »
What are the options for delivery of targeted toxins? The options for toxin delivery are varied and limited only by investigator ingenuity. Generally, injection has been the route of choice. Some toxins can be given intravenously, such as 192-Saporin (192-IgG-SAP, Cat. # IT-01) or anti-DBH-SAP (Cat. # IT-03), in which case all cells expressing p75 …
Targeting Talk: In Vivo Delivery of Targeted Toxins Read More »
Selective destruction of medial septal cholinergic neurons attenuates pyramidal cell suppression, but not excitation in dorsal hippocampus field CA1 induced by subcutaneous injection of formalin. Zheng F, Khanna S. Neuroscience 103(4):985-998, 2001. PMID: 11301206 Previously, the authors have shown that an injection of formalin in the hindpaw of rats will excite a select population of …
Advanced Targeting Systems announces the release of its new, very exciting targeted toxin, dermorphin-SAP. It is a conjugate of the mu opioid receptor (MOR) agonist dermorphin and the ribosome-inactivating protein, saporin. Its cytotoxicity to cells that express the MOR promise to make it an important tool in the discovery and definition of the role of …
Cover Article: Dermorphin-SAP Kills MOR-Positive Cells Read More »