Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights A Field Trip to Torrey Pines State Reserve (page 2) Targeted Toxin Delivery (page 5) Saporin, a Ribosome-Inactivating Protein (page 7)
Saporin is a 30 kDa protein isolated from the seeds of the plant Saponaria officinalis. This pleasant resident of the banks of Southern European streams has long been known for medicinal properties, mainly due to its saponins, detergents that reside especially in the roots of the plant and which give the plant its name. It […]
What are the options for delivery of targeted toxins? The options for toxin delivery are varied and limited only by investigator ingenuity. Generally, injection has been the route of choice. Some toxins can be given intravenously, such as 192-Saporin (192-IgG-SAP, Cat. # IT-01) or anti-DBH-SAP (Cat. # IT-03), in which case all cells expressing p75 […]
Selective destruction of medial septal cholinergic neurons attenuates pyramidal cell suppression, but not excitation in dorsal hippocampus field CA1 induced by subcutaneous injection of formalin. Zheng F, Khanna S. Neuroscience 103(4):985-998, 2001. PMID: 11301206 Previously, the authors have shown that an injection of formalin in the hindpaw of rats will excite a select population of […]
Advanced Targeting Systems announces the release of its new, very exciting targeted toxin, dermorphin-SAP. It is a conjugate of the mu opioid receptor (MOR) agonist dermorphin and the ribosome-inactivating protein, saporin. Its cytotoxicity to cells that express the MOR promise to make it an important tool in the discovery and definition of the role of […]