01q2

Targeting Trends Newsletter 01q2

Below are links to view the quarterly newsletter Targeting Trends. If you would like to be added to the mailing list, please complete the information on our contact page. Newsletter Highlights Cytometry Research partners with Cytomation (page 2) Suicide Transport Explained (page 5) New Controls for Immunotoxins (page 7) [fivecol_one]Page 1Page 2Page 3Page 4Page 5Page 6Page …

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Targeting Talk: Suicide Transport and Immunolesioning

What is immunolesioning? Immunolesioning is a technique for making highly selective cellular lesions using immunotoxins. The immunotoxins consist of a monoclonal antibody to a cell surface molecule and a toxic effect or moiety such as saporin, a ribosome-inactivating protein. The selectivity of the lesion made with this technique depends on the selective expression of the …

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Targeting Topics 01q2

Up-regulation of growth-associated protein 43 mRNA in rat medial septum neurons axotomized by fimbria-fornix transection. Haas CA, Hollerbach E, Deller T, Naumann T, Frotscher M. Eur J Neurosci 12(12):4233-4242, 2000. PMID: 11122335 Axonal growth and regeneration is limited in adult mammals, however if injured CNS neurons are in an environment permissive for growth, they can …

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Safety Studies Begin

Early last month (March 2001), Advanced Targeting Systems (ATS) received funding from the National Institute of Mental Health (NIMH) to begin toxicology/safety studies of Substance P-Saporin (SP-SAP), a potential therapeutic for the treatment of chronic pain. The studies will be completed under the direction of three scientists who are experts in their respective fields. Dr. …

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