Somatostatin Receptor-2 is one of five receptor subtypes termed SSTR1-5. They are G-protein-coupled receptors characterized by seven transmembrane helices with an extracellular amino terminal domain and an intracellular carboxy terminus. These receptors function in the regulation of numerous physiological processes such as the secretion of insulin, glucagon, and growth hormone, as well as cell growth induced by neuronal excitation in both the central and peripheral nervous system. Somatostatin receptors are activated via somatostatin secreted by nerve and endocrine cells.
This antibody was raised against rat somatosatin receptor-2 (SSTR2) and recognizes SSTR2 in human. The somatostatin receptor antisera was developed in rabbit using a peptide corresponding to the extracellular domain conjugated to keyhole limpet hemocyanin (KLH) for immunization. This antibody is routinely tested by immunoblotting.
Applications include immunoblotting and ELISA.
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