Somatostatin Receptor-4 is one of five receptor subtypes termed SSTR1-5. They are G-protein-coupled receptors characterized by seven transmembrane domains with an extracellular amino terminal domain and an intracellular carboxy terminus. These receptors function in the regulation of numerous physiological processes such as the secretion of insulin, glucagon, and growth hormone, as well as cell growth induced by neuronal excitation in both the central and peripheral nervous systems. Somatostatin receptors are activated via somatostatin secretion in nerve and endocrine cells.
This antibody was raised against rat somatostatin receptor-4 (SSTR4) and recognizes SSTR4 in rat. The SSTR antisera was developed in rabbit using a peptide (Cat. #PR-07) corresponding to the extracellular domain conjugated to keyhole limpet hemocyanin (KLH) for immunization. Antisera was then affinity-purified with the peptide utilized for immunization. It has been conjugated to the fluorescent dye Alexa488. The antibody is routinely tested by immunoblotting.
Applications include immunoblotting and ELISA.