Angiotensin II receptor

Zhu L, Liu Z, Huang LP, Zhou HR, Cao Y, Yang XP, Wang BJ, Yang ZL, Chen J (2021) Angiotensin (1-7) alleviates postresuscitation myocardial dysfunction by suppressing oxidative stress through the phosphoinositide 3-kinase, protein kinase b, and endothelial nitric oxide synthase signaling pathway. J Cardiovasc Pharmacol 78(1):e65-e76. doi: 10.1097/fjc.0000000000001037 PMID: 33929390

Objective: To investigate the role of the Ang (1-7)-MasR axis in postresuscitation myocardial dysfunction (PRMD) and its associated mechanism.

Summary: The Ang (1-7)-MasR axis can alleviate PRMD by reducing myocardial tissue damage and oxidative stress through activation of the phosphoinositide 3-kinase-protein kinase B-endothelial nitric oxide synthase signaling pathway and provide a new direction for the clinical treatment of PRMD.

Usage: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Gavini MP, Mahmood A, Belenchia AM, Beauparlant P, Kumar SA, Ardhanari S, DeMarco VG, Pulakat L (2021) Suppression of inflammatory cardiac cytokine network in rats with untreated obesity and pre-diabetes by AT2 receptor agonist NP-6A4. Front Pharmacol 12:693167. doi: 10.3389/fphar.2021.693167 PMID: 34220518

Objective: To determine whether NP-6A4 (a new AT2R peptide agonist with an FDA orphan drug designation for pediatric cardiomyopathy) would mitigate cardiac damage from chronic inflammation induced by untreated obesity.

Summary: Seventeen pro-inflammatory and pro-fibrotic cytokines that increase during lethal cytokine storms caused by infections such as COVID-19 were among the cytokines suppressed by NP-6A4 treatment in ZO rat heart. Thus, NP-6A4 activates a novel anti-inflammatory network comprised of 21 proteins in the heart that was not reported previously. Since NP-6A4’s unique mode of action suppresses pro-inflammatory cytokine network and attenuates myocardial damage, it can be an ideal adjuvant drug with other anti-glycemic, anti-hypertensive, standard-of-care drugs to protect the heart tissues from pro-inflammatory and pro-fibrotic cytokine attack induced by obesity.

Usage: Immunohistochemistry, 5-micrometer heart sections

Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)

Rodríguez-Rodríguez P, Vieira-Rocha MS, Quintana-Villamandos B, Monedero-Cobeta I, Prachaney P, López de Pablo AL, González MDC, Morato M, Diniz C, Arribas SM (2021) Implication of RAS in postnatal cardiac remodeling, fibrosis and dysfunction induced by fetal undernutrition. Pathophysiology 28(2):273-290. doi: 10.3390/pathophysiology28020018 PMID: 35366262

Objective: To assess if alterations in renal artery stenosis (RAS) during lactation participate in cardiac dysfunction associated with fetal undernutrition.

Summary: In rats exposed to fetal undernutrition, RAS disbalance and associated cardiac remodeling during lactation may set the basis for later heart dysfunction.

Usage: Immunohistochemistry (1:50)

Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)

Gonzalez EA, Leitão SAT, Dos Santos Soares D, Tavares AMV, Giugliani R, Baldo G, Matte U (2021) Cardiac pathology in Mucopolysaccharidosis I mice: Losartan modifies ERK1/2 activation during cardiac remodeling. J Inherit Metab Dis 44(3):740-750. doi: 10.1002/jimd.12327 PMID: 33145772

Objective: To investigate whether the pathways influenced by losartan and propranolol may modulate the cardiac remodeling process in MPS I mice.

Summary: Losartan and propranolol restore the heart function and could be used to ameliorate the cardiac disease in MPS I.

Usage: Western Blot 1:400

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Hou G, Jiang Y, Zheng Y, Zhao M, Chen Y, Ren Y, Wang C, Li W (2021) Mechanism of Radix Astragali and Radix Salviae Miltiorrhizae ameliorates hypertensive renal damage. Biomed Res Int eCollection:5598351. doi: 10.1155/2021/5598351 PMID: 33969119

Objective: To explore the mechanism of combination of Radix Astragali (RA) and Radix Salviae Miltiorrhizae (RS) ameliorating HRD by regulation of the renal sympathetic nerve.

Summary: The combination of RA and RS may inhibit the hyperexcitability of sympathetic nerves, reduce Ang II overexpression, avoid abnormal activation of the RAS system, and improve rat renal blood flow resistance, accordingly maintaining the normal physiological structure and function of kidney tissue and having a protective effect on the cardiovascular system.

Usage: Immunohistochemistry (1:150)

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Phipps BL, Suwannasual U, Lucero J, Mitchell NA, Lund AK (2021) Vehicle emissions-exposure alters expression of systemic and tissue-specific components of the renin-angiotensin system and promotes outcomes associated with cardiovascular disease and obesity in wild-type C57BL/6 male mice. Toxicol Rep 8:846-862. doi: 10.1016/j.toxrep.2021.04.001 PMID: 33948438

Objective: To investigate the hypothesis that exposure to engine emissions increases systemic and local adipocyte RAS signaling, promoting the expression of factors involved in cardiovascular disease and obesity.

Summary: Subchronic traffic-generated air pollution exposure (MVE) results in elevated expression of AT1 in the systemic vasculature, which is associated with increased vascular adhesion molecule expression, monocyte/macrophage sequestration, and production of ROS, all of which are early tissue-level signaling events in the pathogenesis of CVD. Furthermore, kidney levels of renin and Ang II receptors, AT1 and AT2, were also elevated with MVE exposure.

Usage: Immunofluorescence (1:1000)

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP), Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)

Kang H, Wang Y, Zhong X, Yin W, Li F, Jiang J (2021) [Effect of salt intake on residual renal function in rats receiving peritoneal dialysis]. Nan Fang Yi Ke Da Xue Xue Bao 41(2):264-271. doi: 10.12122/j.issn.1673-4254.2021.02.15 PMID: 33624601

Objective: To assess the effect of salt intake on residual renal function in rats and explore the possible mechanism.

Summary: In rats with chronic renal failure, high salt intake promotes the activation of the renal RAS system, increases blood pressure, and aggravates renal fibrosis to accelerate the decline of residual renal function, and peritoneal dialysis partially reduces the damage of residual renal function induced by high-salt diets by removing excessive sodium.

Usage: Western Blot.

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Wang CH, Pandey S, Sivalingam K, Shibu MA, Kuo WW, Yu-LanYeh, Viswanadha VP, Lin YC, Liao SC, Huang CY (2021) Leech extract: A candidate cardioprotective against hypertension-induced cardiac hypertrophy and fibrosis. J Ethnopharmacol 264:113346. doi: 10.1016/j.jep.2020.113346 PMID: 32896627

Objective: To delineate the molecular mechanisms of medicinal leech extract in the treatment of cardiac hypertrophy and fibrosis, using both in vitro and in vivo assessments.

Summary: Pre-treatment with leech extract significantly reduced angiotensin II (ANG II)-induced cardiac hypertrophy and fibrosis.

Usage: Western blot; PVDF membranes were incubated with Anti-AT-1R.

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)

Lim I, Mitsui R, Kameda M, Sellers DJ, Chess‐Williams R, Hashitani H (2021) Comparative effects of angiotensin II on the contractility of muscularis mucosae and detrusor in the pig urinary bladder. Neurourol Urodyn 40:102-111. doi: 10.1002/nau.24548 PMID: 33074588

Objective: To explore contractile actions of angiotensin II (AT2) on the muscularis mucosae (MM) of the bladder.

Summary: The MM appears to have great sensitivity to AT2, suggesting that MM may be the predominant target of contractile actions induced by AT2 in the bladder.

Usage: Induction of contractions with Anti-AT2R (1 nM – 1 µM). Immunofluorescence (10-100 pM).

Related Products: Angiotensin II receptor (AT-2R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N28AP)

Bragina ME, Costa-Fraga F, Sturny M, Ebadi B, Ruoccolo RT, Santos RAS, Fraga-Silva RA, Stergiopulos N (2020) Characterization of the renin-angiotensin system in aged cavernosal tissue and its role in penile fibrosis. J Sex Med 17:2129–2140. doi: 10.1016/j.jsxm.2020.08.008 PMID: 32943375

Objective: To investigate local regulation of the renin-angiotensin system (RAS) in age-related erectile dysfunction (ED).

Summary: Experimental results highlighted the essential role of the RAS in modulation of cavernosal fibrosis.

Usage: Immunohistochemistry (1:800)

Related Products: Angiotensin II receptor (AT-1R) Rabbit Polyclonal, affinity-purified (Cat. #AB-N27AP)