Phipps BL, Suwannasual U, Lucero J, Mitchell NA, Lund AK (2021) Vehicle emissions-exposure alters expression of systemic and tissue-specific components of the renin-angiotensin system and promotes outcomes associated with cardiovascular disease and obesity in wild-type C57BL/6 male mice. Toxicol Rep 8:846-862. doi: 10.1016/j.toxrep.2021.04.001 PMID: 33948438
Objective: To investigate the hypothesis that exposure to engine emissions increases systemic and local adipocyte RAS signaling, promoting the expression of factors involved in cardiovascular disease and obesity.
Summary: Subchronic traffic-generated air pollution exposure (MVE) results in elevated expression of AT1 in the systemic vasculature, which is associated with increased vascular adhesion molecule expression, monocyte/macrophage sequestration, and production of ROS, all of which are early tissue-level signaling events in the pathogenesis of CVD. Furthermore, kidney levels of renin and Ang II receptors, AT1 and AT2, were also elevated with MVE exposure.
Usage: Immunofluorescence (1:1000)