References

Amatore F, Ortonne N, Lopez M, Barre M, Orlanducci F, Castellano R, Ingen-Housz_Oro S, De Croos A, Gorvel L, Goubard a< Boubdallah R, De Colella JMC, Grob JJ, Gaulard P, Bagot M, Bensussan A, Delaporte E, Olive D (2021) ICOS is widely expressed in cutaneous T-cell Lyphoma and its targeting promotes potent killing of malignant cells. Blood 138(s1):790 792. doi: 10.1182/blood-2021-150677

Objective: To investigate inducible Co-Stimulator (ICOS), a T-cell co-stimulatory receptor involved in the development of cutaneous T-cell lymphomas (CTCLs).

Summary: ICOS is a promising therapeutic target because it is expressed both by tumor T-cells and regulatory T-cells. Authors report for the first time the strong and frequent expression of ICOS in CTCLs, as well as the preclinical efficacy of anti-ICOS ADCs on a CTCL cell line and Patient Derived Xenografts (PDXs).

Usage: The secondary conjugate, Mab-ZAP (IT-04), was used to determine the ability of the antibody to act as an antibody-drug conjugate.

Related Products: Mab-ZAP (Cat. #IT-04)

Sasaki N, Gusain P, Hayano M, Sugaya T, Tonegawa N, Hatanaka Y, Tamura R, Okuyama K, Osada H, Ban N, Mitsukura Y, Lang RA, Mimura M, Tsubota K (2021) Violet light modulates the central nervous system to regulate memory and mood. bioRxiv 2021.11.02.466604. doi: 10.1101/2021.11.02.466604

Related Products: Melanopsin Rabbit Polyclonal, affinity-purified (Cat. #AB-N39)

Chen X, Liu H, Li A, Ji S, Fei H (2021) Hydrophobicity-tuned anion responsiveness underlies endosomolytic cargo delivery mediated by amphipathic vehicle peptides. J Biol Chem 297(6):101364. doi: 10.1016/j.jbc.2021.101364

Objective: The study focuses on hydrophobicity and a structure-function strategy to evolve a template peptide for endosomolytic cargo delivery.

Summary: The peptide LP6 could dramatically promote cargo cell entry and facilitate cytosolic delivery of biomacromolecules such as saporin.

Usage: HeLa cells were treated with saporin (10, 20, 50μg/ml) in the absence (–) or presence (+) of LP6 (20μM) to confirm the cytosolic delivery ability of LP6.

Related Products: Saporin (Cat. #PR-01)

Sałaciak K, Pytka K (2022) Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders. Neurosci Biobehav Rev 132:1114-1136. doi: 10.1016/j.neubiorev.2021.10.037

Objective: This review focuses on the sigma-1 receptor as a target for treatment of depression and cognitive disorders.

Summary: Sigma-1 receptor ligands, and predominantly agonists, might be the next generation of psychotherapeutic agents.

Usage: 192-IgG-SAP is listed as a neurotoxin that induced a memory impairment in rats based on the Morris water maze.

Related Products: 192-IgG-SAP (Cat. #IT-01)

See Also:

• Antonini V et al. Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J Neurochem 109:744-754, 2009.

Braun JL, Geromella MS, Hamstra SI, Messner HN, Fajardo VA (2021) Characterizing SERCA function in murine skeletal muscles after 35-37 days of spaceflight. Int J Mol Sci 22(21):11764. doi: 10.3390/ijms222111764 PMID: 34769190

Objective: To investigate SERCA function, SERCA regulatory protein content, and reactive oxygen/nitrogen species (RONS) protein adduction in murine skeletal muscle after 35–37 days of spaceflight.

Summary: Spaceflight affects SERCA function differently between the soleus and tibialis anterior.

Usage: Western blot (20 mg)

Related Products: NO-L-Cysteine Mouse Monoclonal, Conjugated (Cat. #AB-T125)

Lodhi MS, Khan MT, Bukhari SMH, Sabir SH, Samra ZQ, Butt H, Akram MS (2021) Probing transferrin receptor overexpression in gastric cancer mice models. ACS Omega 6(44):29893-29904. doi: 10.1021/acsomega.1c04382 PMID: 34778662

Objective: To investigate the role of the transferrin receptor, a glycoprotein receptor that is expressed many-folds on rapidly growing cells due to the greater demand of iron, in gastric cancer.

Summary: A mouse model of gastric cancer has the potential to be used in the future to study the therapeutic effects of cancer medicines, and overexpression of transferrin receptors could be identified through the designed probe to be used as diagnostics.

Related Products: MonoBiotin-ZAP (Cat. #BT-ZAP)

See Also:

• Daniels TR et al. Conjugation of an anti transferrin receptor IgG3-avidin fusion protein with biotinylated saporin results in significant enhancement of its cytotoxicity against malignant hematopoietic cells. Mol Cancer Ther 6:2995-3008, 2007.

Bowers Z, Maiti P, Bourcier A, Morse J, Jenrow K, Rossignol J, Dunbar GL (2021) Tart cherry extract and omega fatty acids reduce behavioral deficits, gliosis, and amyloid-beta deposition in the 5xFAD mouse model of Alzheimer’s disease. Brain Sci 11(11):1423. doi: 10.3390/brainsci11111423 PMID: 34827424

Objective: To assess the efficacy of Total Body Rhythm (TBR) for treating behavioral and neuropathological deficits in the 5xFAD model of AD.

Summary: The combination of tart cherry extract and omega fatty acids in TBR can reduce AD-like deficits in 5xFAD mice.

Usage: Previous work demonstrated that TBR can prevent loss of body weight in a mu p75-SAP mouse model of AD.

Related Products: mu p75-SAP (Cat. #IT-16)

See Also:

• Matchynski JJ et al. Combinatorial treatment of tart cherry extract and essential fatty acids reduces cognitive impairments and inflammation in the mu-p75 saporin-induced mouse model of Alzheimer’s disease. J Med Food 16(4):288-295, 2013.

Arslan I, Aydin O, Birdal P (2021) Naturally occurring ribosome inactivating proteins might be key molecules against Covid-19. 2021 5th International Symposium on Multidisciplinary Studies and Innovative Technologies (ISMSIT) 624-627. Ankara, Turkey. doi: 10.1109/ISMSIT52890.2021.9604711

Summary: The authors cover a variety of topics related to the use of Saporin as a potential molecule to study for the prevention of COVID-19. Other important areas of interest include: Mode of Action of Saporin, Depurination Mechanism, and Apoptosis Induction.

Miranpuri GS, Bali P, Nguyen J, Kim JJ, Modgil S, Mehra P, Buttar S, Brown G, Yutuc N, Singh H, Wood A, Singh J, Anand A (2021) Role of microglia and astrocytes in spinal cord injury induced neuropathic pain. Ann Neurosci 28(3-4):219-228. doi: 10.1177/09727531211046367

Summary: Given the severity and incapacitating effects of spinal cord injury neuropathic pain (SCINP), it is imperative to study the pathways involved and find new therapeutic targets in coordination with stem cell research, and to develop a new gold-standard in SCINP treatment. Chronic inflammation by microglia, when targeted with Mac-1-SAP, helps in pain reversal.

Related Products: Mac-1-SAP rat (Cat. #IT-33)

Chen ZF (2021) A neuropeptide code for itch. Nat Rev Neurosci 22(12):758-776. doi: 10.1038/s41583-021-00526-9

Related Products: Bombesin-SAP (Cat. #IT-40)