Vera-Portocarrero LP, Zhang ET, King T, Ossipov MH, Vanderah TW, Lai J, Porreca F (2007) Spinal NK-1 receptor expressing neurons mediate opioid-induced hyperalgesia and antinociceptive tolerance via activation of descending pathways. Pain 129:35-45. doi: 10.1016/j.pain.2006.09.033
Summary: Administration of opioids can induce hyperalgesia in humans and other mammals. In this work the authors examined the role of NK-1 receptor-expressing neurons in the spinal dorsal horn during a hyperalgesic condition not induced by tissue injury. 5 µl of 10 µM SP-SAP (Cat. #IT-07) was injected into the intrathecal space of rats. Saporin (Cat. #PR-01) was used as a control. Osmotic pumps then delivered morphine. Data from the lesioned animals indicate that NK-1 receptor-expressing neurons play a critical role in this hyperalgesic circuit.
Related Products: SP-SAP (Cat. #IT-07), Saporin (Cat. #PR-01)