Rygh LJ, Suzuki R, Rahman W, Wong Y, Vonsy JL, Sandhu H, Webber M, Hunt S, Dickenson AH (2006) Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons. Eur J Neurosci 24(3):761-772. doi: 10.1111/j.1460-9568.2006.04968.x
Summary: Long-term potentiation (LTP) has been shown to occur in sensory areas of the spinal cord. This modification of synaptic strength may be one of the mechanisms by which acute pain is transformed into chronic pain. 10 µl of 1-µM SP-SAP (Cat. #IT-07) or control saporin (Cat. #PR-01) was injected into the subarachnoid space (L4-L5) of rats. Using electrophysiological recording, immunohistochemistry, behavioral assessment, and antisense experiments, the authors demonstrate that dorsal horn neuron generation of LTP may transform acute pain into chronic pain.
Related Products: SP-SAP (Cat. #IT-07), Saporin (Cat. #PR-01)