Kanai T, Watanabe M, Okazawa A, Sato T, Yamazaki M, Okamoto S, Ishii H, Totsuka T, Iiyama R, Okamoto R, Ikeda M, Kurimoto M, Takeda K, Akira S, Hibi T (2001) Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn’s disease. Gastroenterol 121:875-888. doi: 10.1053/gast.2001.28021
Summary: Crohn’s disease is an inflammatory bowel disease that is associated with several changes in the immune system, including an increased number of infiltrating macrophages. These macrophages release a variety of cytokines that are responsible for inflammation. The authors investigated the role of these macrophages in a mouse model by eliminating them with Mac-1-SAP (20 µg parenterally in tail vein; Cat. #IT-06). Seven days after treatment, mice showed no evidence of intestinal inflammation. These data demonstrate the role of macrophages in the development of inflammatory bowel conditions.