Chen LQ, Lv XJ, Guo QH, Lv SS, Lv N, Xu WD, Yu J, Zhang YQ (2023) Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia in rodents. Br J Pharmacol 180(8):1090-1113. doi: 10.1111/bph.15994 PMID: 36443951
Objective: To determine whether and how microglia are involved in trigeminal neuralgia-induced anxiodepression.
Summary: Findings suggest that priming of microglia with ATP/P2X7 receptors in the ipsilateral hippocampus drives pain-related anxiodepressive-like behaviors via IL-1β. An asymmetric role of the bilateral hippocampus in trigeminal neuralgia-induced anxiety and depression was uncovered.
Usage: Mac-1–SAP (IT-06, 2.5 μg/1 μl, per side) was bilaterally injected into the hippocampal CA1 area on Day 0 and Day 7 after constriction of the infraorbital nerve, respectively. Unconjugated saporin was used as a control.
Related Products: Saporin (Cat. #PR-01), Mac-1-SAP mouse/human (Cat. #IT-06)