Designing coiled-coil peptide materials for biomedical applications

Jorgensen MD (2023) Designing coiled-coil peptide materials for biomedical applications. Purdue University Thesis.

Objective: Using saporin [PR-01] containing hydrogel to target and eliminate cancer cells.

Summary: Hydrogels can bind molecular cargo and be used to shuttle cytotoxic drugs across the body. Using a pH-responsive hyaluronic acid nanogel containing saporin, cancer cells with overexpressed CD44 receptor are eliminated.

Related Products: Saporin (Cat. #PR-01), Anti-CD44-SAP (Cat. #IT-72)

See Also:

• Ding L, Jiang Y, Zhang J, Klok HA, Zhong Z (2018) pH-Sensitive Coiled-Coil Peptide-Cross-Linked Hyaluronic Acid Nanogels: Synthesis and Targeted Intracellular Protein Delivery to CD44 Positive Cancer Cells. Biomacromolecules 19(2):555-562. doi: 10.1021/acs.biomac.7b01664 PMID: 29284258