CD44 is a cell-surface glycoprotein that plays a role in cell-cell interactions, cell adhesion and migration. CD44 is a receptor for hyaluronic acid and also interacts with other ligands, such as osteopontin, collagens, and matrix metalloproteinases. CD44 participates in a wide variety of cellular functions such a lymphocyte activation, recirculation and homing, hematopoieses, and tumor metastasis. CD44 has been considered an activity marker and potential novel therapeutic target in multiple sclerosis and is associated with relapses in non-small cell lung cancers.
Anti-CD44-SAP is a bonded toxin between biotinylated rat monoclonal antibody to mouse CD44 (clone IM7) and the secondary conjugate Streptavidin-ZAP containing the ribosome-inactivating protein, saporin. It eliminates cells expressing all isoforms of CD44 with expected reactivity in mouse, human, baboon, monkey, bovine, cat, dog, ferret, horse, pig, cynomolgus monkey, and rhesus monkey.