Hoffman S, Alvares D, Adeli K (2022) GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein. Mol Metab 65:101590. doi: 10.1016/j.molmet.2022.101590 PMID: 36067913
Objective: To examine the effect of vagal GLP-1 signaling on intestinal fat absorption and lipoprotein production.
Summary: Selective deafferentation of GLP-1R-containing nodose neurons with GLP-1R (Exenatide)-SAP caused significant increases in postprandial (but not fasting) plasma TG, plasma cholesterol, and TRL TG following an olive oil gavage. Over a 2-week period, increased food consumption and elevated liver lipids were also observed.
Usage: GLP-1R-SAP or Blank-SAP was administered to Syrian golden hamsters (bilateral nodose ganglia; 1 µg/1 µl).
Related Products: Ex4-SAP (GLP-1-SAP) (Cat. #IT-90), Blank-SAP (Cat. #IT-21)