Ex4-SAP (GLP-1-SAP) [IT-90, KIT-90]

a tool for eliminating cells that express GLP-1R; targeted via exendin-4, eliminated via saporin

SKU: IT-90 Category: Conjugate: saporin | Usage: eliminates cells |
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Exenatide is a synthetic version of exendin-4, a hormone found in the saliva of the Gila monster.  It displays biological properties similar to human glucagon-like peptide-1 (GLP-1), a regulator of glucose metabolism and insulin secretion. Exenatide is a 39-amino-acid peptide that enhances glucose-dependent insulin secretion by the pancreatic beta-cell, suppresses inappropriately elevated glucagon secretion, slows gastric emptying, presents a subtle yet prolonged effect to reduce appetite and promote satiety via hypothalamic receptors, and reduces liver fat content. Exenatide demonstrates a 50% greater half-life than native GLP-1 in vivo and is DPP-4 resistant.

Ex4-SAP is a bonded conjugate of exendin-4 peptide, a glucagon-like peptide-1 (GLP-1) agonist and the ribosome-inactivating protein, saporin. It eliminates cells expressing the GLP-1 receptor.

Ex4-SAP-SAP is available individually (Cat. #IT-90) or as a kit (Cat. #KIT-90) which includes Ex4-SAP and Blank-Streptavidin-SAP (Cat. #IT-27B).