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Cholinergic signaling, neural excitability, and epilepsy

Wang Y, Tan B, Wang Y, Chen Z (2021) Cholinergic signaling, neural excitability, and epilepsy. Molecules 26(8):2258. doi: 10.3390/molecules26082258

Summary: In this review, the authors briefly describe the distribution of cholinergic neurons, muscarinic, and nicotinic receptors in the central nervous system and their relationship with neural excitability and epilepsy. intraventricular administration of 192-IgG-SAP, which inhibits cholinergic projection to the hippocampus and cortex respectively, facilitates seizure induced by amygdala kindling

Usage: Ferencz et al. used 192-IgG-SAP (2.5 μg icv) to investigate the effect of eliminating cholinergic projections to the hippocampal formation and cerebral cortex on the induction of epilepsy through electrical stimulation of the rat brain. They determined that the loss of specific projections to the amygdala accelerates development of seizures.

See: Ferencz I et al. Basal forebrain neurons suppress amygdala kindling via cortical but not hippocampal cholinergic projections in rats. Eur J Neurosci 12:2107-2116, 2000.

Related Products: 192-IgG-SAP (Cat. #IT-01)