Wang Y, Tan B, Wang Y, Chen Z (2021) Cholinergic signaling, neural excitability, and epilepsy. Molecules 26(8):2258. doi: 10.3390/molecules26082258
Summary: In this review, the authors briefly describe the distribution of cholinergic neurons, muscarinic, and nicotinic receptors in the central nervous system and their relationship with neural excitability and epilepsy. intraventricular administration of 192-IgG-SAP, which inhibits cholinergic projection to the hippocampus and cortex respectively, facilitates seizure induced by amygdala kindling
Usage: Ferencz et al. used 192-IgG-SAP (2.5 μg icv) to investigate the effect of eliminating cholinergic projections to the hippocampal formation and cerebral cortex on the induction of epilepsy through electrical stimulation of the rat brain. They determined that the loss of specific projections to the amygdala accelerates development of seizures.
Related Products: 192-IgG-SAP (Cat. #IT-01)