Ferencz I, Leanza G, Nanobashvili A, Kokaia M, Lindvall O (2000) Basal forebrain neurons suppress amygdala kindling via cortical but not hippocampal cholinergic projections in rats. Eur J Neurosci 12:2107-2116. doi: 10.1046/j.1460-9568.2000.00077.x
Summary: Cholinergic mechanisms have been implicated in human epilepsy, possibly in the role of seizure suppression. Ferencz et al. used 2.5 µg 192-Saporin (Cat. #IT-01) by i.c.v. injection to investigate the effect of eliminating cholinergic projections to the hippocampal formation and cerebral cortex on the induction of epilepsy through electrical stimulation of the rat brain. The researchers used the specificity of 192-Saporin to determine that the loss of specific projections to the amygdala accelerates development of seizures. The hippocampus does not influence this process.
Related Products: 192-IgG-SAP (Cat. #IT-01)