I’anson H, Jethwa PH, Warner A, Ebling FJ (2011) Histaminergic regulation of seasonal metabolic rhythms in Siberian hamsters. Physiol Behav 103(3-4):268-278. doi: 10.1016/j.physbeh.2011.02.035
Summary: The role of central histaminergic mechanisms on seasonal catabolic state was investigated in hamsters. Siberian hamsters received bilateral 3.8-ng injections of orexin-SAP (Cat. #IT-20) into the tuberomammillary posterior hypothalamic region. Saporin (Cat. #PR-01) was used as a control. During long days, lesioned animals displayed higher locomotor activity, greater oxygen intake, and no net weight gain. During shorter days (hibernation) with less activity, lesioned animals did not lose weight. The data indicate that histaminergic neurons are involved in body weight regulation.