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Loss of leptin receptor-expressing cells in the hindbrain decreases forebrain leptin sensitivity.

Harris RBS (2020) Loss of leptin receptor-expressing cells in the hindbrain decreases forebrain leptin sensitivity. Am J Physiol Endocrinol Metab 318(5):E806-E816. doi: 10.1152/ajpendo.00020.2020

Objective: This study tested whether loss of hindbrain leptin receptor signaling changed sensitivity to forebrain leptin.

Summary: Loss of VMH (ventromedial nucleus of hippocampus) leptin receptor-expressing cells prevents weight loss. The integrated response between the hindbrain and forebrain is heavily dependent upon leptin activity in the VMH.

Usage: To test forebrain leptin sensitivity Leptin-SAP and Blank-SAP rats received third ventricle injections of 0, 0.05, 0.1, 0.25 or 0.5 μg leptin.

Related Products: Leptin-SAP (Cat. #IT-47), Blank-SAP (Cat. #IT-21)