Potes CS, Turek VF, Cole RL, Vu C, Roland BL, Roth JD, Riediger T, Lutz TA (2010) Noradrenergic neurons of the area postrema mediate amylin’s hypophagic action. Am J Physiol Regul Integr Comp Physiol 299(2):R623-631. doi: 10.1152/ajpregu.00791.2009
Summary: Amylin decreases food intake in rats and is a satiation signal affecting the area postrema (AP). This work investigated the role of noradrenergic neurons in amylin activity. Rats received a total of 50 ng of anti-DBH-SAP (Cat. #IT-03) into the AP and 25 ng into the lateral parabrachial nucleus. Mouse IgG-SAP (Cat. #IT-18) was used as a control. Rats showing a >50% lesion of noradrenergic neurons were unresponsive to low doses of amylin, suggesting that noradrenergic neurons are part of the amylin pathway.
Related Products: Anti-DBH-SAP (Cat. #IT-03), Mouse IgG-SAP (Cat. #IT-18)