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Noradrenergic nuclei that receive sensory input during mating and project to the ventromedial hypothalamus play a role in mating-induced pseudopregnancy in the female rat.

Noradrenergic nuclei that receive sensory input during mating and project to the ventromedial hypothalamus play a role in mating-induced pseudopregnancy in the female rat.

Northrop LE, Polston EK, Erskine MS (2010) Noradrenergic nuclei that receive sensory input during mating and project to the ventromedial hypothalamus play a role in mating-induced pseudopregnancy in the female rat. J Neuroendocrinol 22(10):1061-1071. doi: 10.1111/j.1365-2826.2010.02049.x

Summary: Maintenance of pregnancy or pseudopregnancy in rats is maintained by bicircadian prolactin surges induced by vaginal-cervical stimulation. In order to test the hypothesis that medullary noradrenergic cell groups are involved in this process the authors infused rats with either 2 ng or 60 ng anti-DBH-SAP (Cat. #IT-03) into the ventrolateral division of the ventromedial hypothalamus (VMHv1) and the posterodorsal medial amygdala. Mouse IgG-Sap (Cat. #IT-18) was used as a control. The data confirm that noradrenergic neurons are involved in the maintenance of pregnancy or pseudopregnancy.