Domico LM, Cooper KR, Bernard LP, Zeevalk GD (2007) Reactive oxygen species generation by the ethylene-bis-dithiocarbamate (EBDC) fungicide mancozeb and its contribution to neuronal toxicity in mesencephalic cells. Neurotoxicology 28:1079-1091. doi: 10.1016/j.neuro.2007.04.008 PMID: 17597214
Summary: This work explores the mechanisms of neuronal damage associated with the ethylene-bis-dithiocarbamate fungicide mancozeb (MZ). In order to obtain a purified rat mesencephalic culture, the authors treated neuronal cultures with Mac-1-SAP (Cat. #IT-33) at a final concentration of 2 µg/ml. The microglia-free cultures did not display attenuated reactive oxygen species (ROS) production when treated with MZ. The data suggest that microglia are not required for ROS production in the presence of MZ.
Related Products: Mac-1-SAP rat (Cat. #IT-33), Antibody to Mac-1 (Cat. #AB-N06)