1. Home
  2. Knowledge Base
  3. References
  4. Targeting the niche: Depleting haemopoietic stem cells with targeted therapy.

Targeting the niche: Depleting haemopoietic stem cells with targeted therapy.

Abadir E, Bryant C, Larsen S, Clark GJ (2019) Targeting the niche: Depleting haemopoietic stem cells with targeted therapy. Bone Marrow Transplant 54:961–968. doi: 10.1038/s41409-019-0445-0

Summary: Anti-mouse CD45 ADC (clone 104-Saporin) Depletes mature lymphoid cells and HSPC, conditioning allows for high level sustained multilineage engraftment of congenic mice. Anti-mouse ADC (CD117-saporin) Combined with T cell depleting agents allowed for significant and durable engraftment in an immunocompetent mouse allo-HSCT model.

Related Products: Streptavidin-ZAP (Cat. #IT-27)