Author name: Kristen Hartman

A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs.

Driessen AK, McGovern AE, Behrens R, Moe AAK, Farrell MJ, Mazzone SB (2020) A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs. J Physiol 598(11):2257-2275. doi: 10.1113/JP279644 Objective: This study aimed to assess the involvement of paratrigeminal neurokinin 1 receptor neurons in the regulation of cough, breathing […]

A role for neurokinin 1 receptor expressing neurons in the paratrigeminal nucleus in bradykinin-evoked cough in guinea-pigs. Read More »

A DNA-based fluorescent probe maps NOS3 activity with subcellular spatial resolution.

Jani MS, Zou J, Veetil AT, Krishnan Y (2020) A DNA-based fluorescent probe maps NOS3 activity with subcellular spatial resolution. Nat Chem Biol 16:660–666. doi: 10.1038/s41589-020-0491-3 PMID: 32152543 Objective: Usage of novel fluorescent DNA-based probe technology to map activities of endogenous NOS3 in live cells provides a platform to discover selective regulators of NOS3 in

A DNA-based fluorescent probe maps NOS3 activity with subcellular spatial resolution. Read More »

Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer antibody-drug conjugates (ADCs)

Hoffmann RM, Mele S, Cheung A, Larcombe-Young D, Bucaite G, Sachouli E, Zlatareva I, Morad HOJ, Marlow R, McDonnell JM, Figini M, Lacy KE, Tutt AJN, Spicer JF, Thurston DE, Karagiannis SN, Crescioli S (2020) Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer antibody-drug conjugates (ADCs). Sci Rep 10(1):8869.

Rapid conjugation of antibodies to toxins to select candidates for the development of anticancer antibody-drug conjugates (ADCs) Read More »

Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts

Xiao D, Deng Q, Guo Y, Huang X, Zou M, Zhong J, Rao P, Xu Z, Liu Y, Hu Y, Shen Y, Jin K, Xiang M (2020) Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts. Sci Adv 6(22):eaaz5858. doi: 10.1126/sciadv.aaz5858 PMID: 32523990 Objective: To examine whether sensory ganglion (SG) organoids can

Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts Read More »

Acetylcholine and spontaneous recognition memory in rodents and primates.

Easton A, Barros M, Lever C (2020) Acetylcholine and spontaneous recognition memory in rodents and primates. Curr Top Behav Neurosci 45:29-45. doi: 10.1007/7854_2020_132 Summary: Review of lesioning designed to specifically target cells that express acetylcholine as a transmitter. Related Products: 192-IgG-SAP (Cat. #IT-01)

Acetylcholine and spontaneous recognition memory in rodents and primates. Read More »

Cholinergic signaling dynamics and cognitive control of attention.

Parikh V, Bangasser DA (2020) Cholinergic signaling dynamics and cognitive control of attention. Shoaib M., Wallace T (Ed.): Behavioral Pharmacology of the Cholinergic System. Current Topics in Behavioral Neurosciences. 45:71-87. Springer, Cham doi: 10.1007/7854_2020_133 Summary: A plethora of studies conducted in rodents demonstrated that selective lesions of BF cholinergic neurons and their cortical inputs produced

Cholinergic signaling dynamics and cognitive control of attention. Read More »

The role of the renin-angiotensin system in regulating endometrial neovascularization during the peri-implantation period: literature review and preliminary data

Qi R, Li TC, Chen X (2020) The role of the renin-angiotensin system in regulating endometrial neovascularization during the peri-implantation period: literature review and preliminary data. Ther Adv Endocrinol Metab 11:2042018820920560. doi: 10.1177/2042018820920560 PMID: 32499907 Objective: The role of the renin–angiotensin system (RAS) in the peri-implantation endometrium. Summary: Altered vasculature of the endometrium in the

The role of the renin-angiotensin system in regulating endometrial neovascularization during the peri-implantation period: literature review and preliminary data Read More »

Intra-articular injection of 2-pyridylethylamine produces spinal NPY-mediated antinociception in the formalin-induced rat knee-joint pain model

Souza-Silva E, Stein T, Mascarin LZ, Dornelles FN, Bicca MA, Tonussi CR (2020) Intra-articular injection of 2-pyridylethylamine produces spinal NPY-mediated antinociception in the formalin-induced rat knee-joint pain model. Brain Res 1735:146757. doi: 10.1016/j.brainres.2020.146757 PMID: 32135147 Objective: To investigate the participation of spinal NPY in the antinociceptive effect produced by 2-pyridylethylamine (2-PEA). Summary: These data support

Intra-articular injection of 2-pyridylethylamine produces spinal NPY-mediated antinociception in the formalin-induced rat knee-joint pain model Read More »

Loss of leptin receptor-expressing cells in the hindbrain decreases forebrain leptin sensitivity.

Harris RBS (2020) Loss of leptin receptor-expressing cells in the hindbrain decreases forebrain leptin sensitivity. Am J Physiol Endocrinol Metab 318(5):E806-E816. doi: 10.1152/ajpendo.00020.2020 Objective: This study tested whether loss of hindbrain leptin receptor signaling changed sensitivity to forebrain leptin. Summary: Loss of VMH (ventromedial nucleus of hippocampus) leptin receptor-expressing cells prevents weight loss. The integrated

Loss of leptin receptor-expressing cells in the hindbrain decreases forebrain leptin sensitivity. Read More »

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