1. Home
  2. Knowledge Base
  3. References
  4. A DNA-based fluorescent probe maps NOS3 activity with subcellular spatial resolution.

A DNA-based fluorescent probe maps NOS3 activity with subcellular spatial resolution.

Jani MS, Zou J, Veetil AT, Krishnan Y (2020) A DNA-based fluorescent probe maps NOS3 activity with subcellular spatial resolution. Nat Chem Biol 16:660–666. doi: 10.1038/s41589-020-0491-3

Objective: Usage of novel fluorescent DNA-based probe technology to map activities of endogenous NOS3 in live cells provides a platform to discover selective regulators of NOS3 in PM and TGN.

Summary: Targeting of plasma membrane (PM) and trans-Golgi network (TGN) shows that NOS3 is tenfold less active at the Golgi but its activity is essential for the structural integrity of the Golgi.

Usage: immunofluorescence

Related Products: NO-L-Cysteine Mouse Monoclonal, Conjugated (Cat. #AB-T125)

Browse Articles

Need Support?

Can't find what you're looking for? Contact us, we're here to help!