Contributed by Dr. Thomas Beach, Sun Health Research Institute, Sun City, AZ Our hypothesis, developed through our own human and animal studies1-6 and the cell culture work of others (beginning with Nitsch7), is that the normal, age-related loss of cortical cholinergic innervation leads to Aβ deposition and Alzheimer’s disease. To test this hypothesis, we have been […]
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Silveira DC, Holmes GL, Schachter SC, Geula C, Schomer DL (2000) Increased susceptibility to generalized seizures after immunolesions of the basal forebrain cholinergic neurons in rats. Brain Res 878:223-227. doi: 10.1016/s0006-8993(00)02703-7 Usage: 192-SAP (Cat. #IT-01), 4 µg intracerebroventricular injection Related Products: 192-IgG-SAP (Cat. #IT-01)
Taylor BK, Roderick RE, Basbaum AI (2000) Brainstem noradrenergic control of nociception is abnormal in the spontaneously hypertensive rat. Neurosci Lett 291:139-142. doi: 10.1016/s0304-3940(00)01389-6 Usage: anti-DBH-SAP (Cat. #IT-03), 5 µg Related Products: Anti-DBH-SAP (Cat. #IT-03)
Wiley RG (2000) Neuropeptide-toxin conjugates in pain research and treatment. (Review). Reg Anesth Pain Med 25(5):546-548. doi: 10.1053/rapm.2000.8457 Summary: Several lines of evidence indicate dorsal horn neurons that respond to substance P (SP) play a role in nociception. Wiley discusses the attributes of SP-SAP (Cat. #IT-07), a targeted toxin that eliminates cells expressing the neurokinin-1
Neuropeptide-toxin conjugates in pain research and treatment. (Review) Read More »
McNerney ME, Pardi D, Pugh PC, Nai Q, Margiotta JF (2000) Expression and channel properties of alpha-bungarotoxin-sensitive acetylcholine receptors on chick ciliary and choroid neurons. J Neurophysiol 84(3):1314-1329. doi: 10.1152/jn.2000.84.3.1314 PMID: 10980005 Related Products: Nicotinic Acetylcholine Receptor alpha 1 (mAb 35) Rat Monoclonal (Cat. #AB-N36)
Bannerman P, Nichols W, Puhalla S, Oliver T, Berman M, Pleasure D (2000) Early migratory rat neural crest cells express functional gap junctions: Evidence that neural crest cell survival requires gap junction function. J Neurosci Res 61:605-615. doi: 10.1002/1097-4547(20000915)61:63.0.CO;2-U PMID: 10972957 Summary: Gap junctions are vital for intercellular communication, especially during development. Neural crest cells
Barnett SC, Alexander CL Iwashita Y, Gilson JM, Crowther J, Clark L, Dunn KT, Papanastassiou V, Kennedy PG, Franklin RJ (2000) Identification of a human olfactory ensheathing cell that can effect transplant mediated remyelination of demyelinated CNS axons. Brain 123:1581-1588. doi: 10.1093/brain/123.8.1581 PMID: 10908188 Related Products: NGFr (mu p75) Rabbit Polyclonal (Cat. #AB-N01)
Schreihofer AM, Guyenet PG (2000) Sympathetic reflexes after depletion of bulbospinal catecholaminergic neurons with anti-DBH-saporin. Am J Physiol Regul Integr Comp Physiol 279:R729-R742. doi: 10.1152/ajpregu.2000.279.2.R729 Related Products: Anti-DBH-SAP (Cat. #IT-03) Read the featured article in Targeting Trends.
Hunt SP (2000) Pain control: breaking the circuit. Trends Pharmacol Sci 21:284-287. doi: 10.1016/s0165-6147(00)01496-6 Summary: Review and analysis of the value of SP-SAP in research and as a therapeutic. Related Products: SP-SAP (Cat. #IT-07)
Pain control: breaking the circuit. Read More »
Herron P, Schweitzer JB (2000) Effects of cholinergic depletion on neural activity in different laminae of the rat barrel cortex. Brain Res 872:71-76. doi: 10.1016/s0006-8993(00)02454-9 Summary: 192-SAP (Cat. #IT-01) 8.0 µg/300 g body weight, nucleus basalis of Meynert Related Products: 192-IgG-SAP (Cat. #IT-01)