Author name: Kristen Hartman

Can Src protein tyrosine kinase inhibitors be combined with opioid analgesics? Src and opioid-induced tolerance, hyperalgesia and addiction

Li Y, Bao Y, Zheng H, Qin Y, Hua B (2021) Can Src protein tyrosine kinase inhibitors be combined with opioid analgesics? Src and opioid-induced tolerance, hyperalgesia and addiction. Biomed Pharmacother 139:111653. doi: 10.1016/j.biopha.2021.111653 Summary: In this review the authors discuss the important role Src protein tyrosine kinase plays in the adverse consequences of clinical […]

Can Src protein tyrosine kinase inhibitors be combined with opioid analgesics? Src and opioid-induced tolerance, hyperalgesia and addiction Read More »

Angiotensin (1-7) alleviates postresuscitation myocardial dysfunction by suppressing oxidative stress through the phosphoinositide 3-kinase, protein kinase b, and endothelial nitric oxide synthase signaling pathway

Zhu L, Liu Z, Huang LP, Zhou HR, Cao Y, Yang XP, Wang BJ, Yang ZL, Chen J (2021) Angiotensin (1-7) alleviates postresuscitation myocardial dysfunction by suppressing oxidative stress through the phosphoinositide 3-kinase, protein kinase b, and endothelial nitric oxide synthase signaling pathway. J Cardiovasc Pharmacol 78(1):e65-e76. doi: 10.1097/fjc.0000000000001037 PMID: 33929390 Objective: To investigate the

Angiotensin (1-7) alleviates postresuscitation myocardial dysfunction by suppressing oxidative stress through the phosphoinositide 3-kinase, protein kinase b, and endothelial nitric oxide synthase signaling pathway Read More »

PARVing the way to cap translation for seizure control

Gross C (2021) PARVing the way to cap translation for seizure control. Epilepsy Curr 21(5):360-362. doi: 10.1177/15357597211027010 Summary: Loss of GABAergic interneurons leads to spontaneous recurrent seizures that persist over months if the amount and spatial spread of initial inhibitory neuron loss is sufficient. Usage: Intrahippocampal injections of SSP-SAP (0.4 ng/10 nL) were performed using

PARVing the way to cap translation for seizure control Read More »

Studying human nociceptors: from fundamentals to clinic

Middleton SJ, Barry AM, Comini M, Li Y, Ray PR, Shiers S, Themistocleous AC, Uhelski ML, Yang X, Dougherty PM, Price TJ, Bennett DL (2021) Studying human nociceptors: from fundamentals to clinic. Brain 144(5):1312-1335. doi: 10.1093/brain/awab048 Summary: The authors injected 5 µg of IB4-SAP into the sciatic nerve in the left thigh. Lesioned animals displayed

Studying human nociceptors: from fundamentals to clinic Read More »

Neurotoxic effects, mechanisms, and outcome of 192 IgG-Saporin lesions.

Petrosini L, De Bartolo P, Cutuli D (2021) Neurotoxic effects, mechanisms, and outcome of 192 IgG-Saporin lesions. RM Kostrzewa (Ed.): Handbook of Neurotoxicity . Springer, Cham doi: 10.1007/978-3-030-71519-9_79-1 Summary: 192-IgG-saporin selectively destroys basal forebrain cholinergic neurons that provide cholinergic input to the hippocampus, entire cortical mantle, amygdala, and olfactory bulb. Immunotoxic lesions by 192-IgG-saporin represent

Neurotoxic effects, mechanisms, and outcome of 192 IgG-Saporin lesions. Read More »

Suppression of inflammatory cardiac cytokine network in rats with untreated obesity and pre-diabetes by AT2 receptor agonist NP-6A4

Gavini MP, Mahmood A, Belenchia AM, Beauparlant P, Kumar SA, Ardhanari S, DeMarco VG, Pulakat L (2021) Suppression of inflammatory cardiac cytokine network in rats with untreated obesity and pre-diabetes by AT2 receptor agonist NP-6A4. Front Pharmacol 12:693167. doi: 10.3389/fphar.2021.693167 PMID: 34220518 Objective: To determine whether NP-6A4 (a new AT2R peptide agonist with an FDA

Suppression of inflammatory cardiac cytokine network in rats with untreated obesity and pre-diabetes by AT2 receptor agonist NP-6A4 Read More »

Specific phospholipid modulation by muscarinic signaling in a rat lesion model of Alzheimer’s disease

Llorente-Ovejero A, Martínez-Gardeazabal J, Moreno-Rodríguez M, Lombardero L, González de San Román E, Manuel I, Giralt MT, Rodríguez-Puertas R (2021) Specific phospholipid modulation by muscarinic signaling in a rat lesion model of Alzheimer’s disease. ACS Chem Neurosci 12(12):2167-2181. doi: 10.1021/acschemneuro.1c00169 PMID: 34037379 Objective: To evaluate the lipid composition and muscarinic signaling in brain areas related

Specific phospholipid modulation by muscarinic signaling in a rat lesion model of Alzheimer’s disease Read More »

Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing

Vicario N, Spitale FM, Tibullo D, Giallongo C, Amorini AM, Scandura G, Spoto G, Saab MW, D’Aprile S, Alberghina C, Mangione R, Bernstock JD, Botta C, Gulisano M, Buratti E, Leanza G, Zorec R, Vecchio M, Di Rosa M, Li Volti G, Lazzarino G, Parenti R, Gulino R (2021) Clobetasol promotes neuromuscular plasticity in mice

Clobetasol promotes neuromuscular plasticity in mice after motoneuronal loss via sonic hedgehog signaling, immunomodulation and metabolic rebalancing Read More »

Efficacy and selectivity of FGF2-saporin cytosolically delivered by PCI in cells overexpressing FGFR1

Vikan AK, Kostas M, Haugsten EM, Selbo PK, Wesche J (2021) Efficacy and selectivity of FGF2-saporin cytosolically delivered by PCI in cells overexpressing FGFR1. Cells 10(6):1476. doi: 10.3390/cells10061476 Summary: Fibroblast growth factor receptors (FGFRs) have become an attractive target in cancer research and therapy due to their implication in several cancers. The authors evaluated the

Efficacy and selectivity of FGF2-saporin cytosolically delivered by PCI in cells overexpressing FGFR1 Read More »

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