Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders

Sałaciak K, Pytka K (2022) Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders. Neurosci Biobehav Rev 132:1114-1136. doi: 10.1016/j.neubiorev.2021.10.037

Objective: This review focuses on the sigma-1 receptor as a target for treatment of depression and cognitive disorders.

Summary: Sigma-1 receptor ligands, and predominantly agonists, might be the next generation of psychotherapeutic agents.

Usage: 192-IgG-SAP is listed as a neurotoxin that induced a memory impairment in rats based on the Morris water maze.

Related Products: 192-IgG-SAP (Cat. #IT-01)

See Also:

• Antonini V et al. Anti-amnesic properties of (+/-)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats. J Neurochem 109:744-754, 2009.